2025 Italian Open – Men's singles
Carlos Alcaraz defeated Jannik Sinner in the final, 7–6, 6–1 to win the men's singles tennis title at the 2025 Italian Open. It was his seventh Masters 1000 title and 19th career title. Alcaraz also became the second-youngest man, after Rafael Nadal, to reach the quarterfinals of all nine ATP 1000 events.
Alexander Zverev was the defending champion, but lost in the quarterfinals to Lorenzo Musetti.
This tournament marked world No. 1 Sinner's first professional appearance since the 2025 Australian Open, having served a three-month suspension after reaching a case resolution agreement with the World Anti-Doping Agency. Sinner was the first Italian man to reach the final since Adriano Panatta in 1978. His loss ended a 26-match winning streak, dating to the 2024 Shanghai Masters.
Seeds
All seeds received a bye into the second round.Draw
Finals
Seeded players
The following are the projected seeded players, based on live ATP rankings as of 4 May 2025. Actual seedings will be based on ATP rankings as of 5 May 2025. Rankings and points before are as of 5 May 2025.| Seed | Rank | Player | Points before | Points defending | Points earned | Points after | Status | |||
| 1 | 1 |  Withdrawn seeded playersThe following player would have been seeded, but withdrew before the tournament began.
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