2024–25 AFC Champions League Two knockout stage

The knockout stage of the 2024–25 AFC Champions League Two was played from 11 February to 17 May 2025. A total of 16 teams compete in the knockout stage.

Qualified teams

The following teams advanced from the group stage.

Region	Group	Winners	Runners-up
West Region	A	Tractor	Al-Wakrah
West Region	B	Al Taawoun	Al-Khaldiya
West Region	C	Sharjah	Al-Wehdat
West Region	D	Shabab Al Ahli	Al-Hussein
East Region	E	Sanfrecce Hiroshima	Sydney FC
East Region	F	Lion City Sailors	Port
East Region	G	Bangkok United	Nam Định
East Region	H

Format

In the knockout stage, the 16 teams played a single-elimination tournament. Each tie was played on a home-and-away two-legged basis, except the final which was played as a single match. Extra time and penalty shoot-out would be used to decide the winners if necessary. The order of matches would be determined at the draw, except for the final. The final venue was pre-determined on a rotation basis, with the match hosted by the team from the East Region. The draw for the knockout stage was held on 12 December 2024.

Schedule

The schedule of the competition is as follows.

Bracket

Round of 16

Summary

The first legs were played on 11, 12 and 13 February, and the second legs on 18, 19 and 20 February 2025.

West Region

1–1 on aggregate; ''Sharjah won 3–0 on penalties.
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Tractor won 5–4 on aggregate.
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Shabab Al Ahli won 6–3 on aggregate.
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4–4 on aggregate; Al Taawoun won 4–3 on penalties.''

East Region

Sanfrecce Hiroshima won 7–0 on aggregate.
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Sydney FC won 5–4 on aggregate.
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Jeonbuk Hyundai Motors won 5–0 on aggregate.
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''Lion City Sailors won 7–2 on aggregate.''

Quarter-finals

Summary

West Region

2–2 on aggregate; Al Taawoun won 4–2 on penalties.
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''2–2 on aggregate; Sharjah won 5–4 on penalties.''

East Region

Lion City Sailors won 4–1 on aggregate.
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''Sydney FC won 5–2 on aggregate.''

Semi-finals

Summary

West Region

''Sharjah won 2–1 on aggregate.''

East Region

''Lion City Sailors won 2–1 on aggregate.''

Final

The final was played on 18 May 2025, with the team from the East region hosting the final.