2022 Serbia Open

The 2022 Serbia Open was a tennis tournament played on outdoor clay courts. It was the 6th edition of the tournament and was classified as an ATP Tour 250 event on the 2022 ATP Tour. The event took place in Belgrade, Serbia, from 18 to 24 April 2022.

Champions

Andrey Rublev def. Novak Djokovic, 6–2, 6–7, 6–0

Ariel Behar / Gonzalo Escobar def. Nikola Mektić / Mate Pavić, 6–2, 3–6,

_{*per team}

The following players received wildcards into the main draw:

The following player received entry using a protected ranking into the singles main draw:

The following players received entry from the qualifying draw:

The following pairs received wildcards into the doubles main draw:

; Before the tournament