2022 Monte-Carlo Masters – Singles
Defending champion Stefanos Tsitsipas defeated Alejandro Davidovich Fokina in the final, 6–3, 7–6 to win the singles tennis title at the 2022 Monte-Carlo Masters. He became the sixth player to win consecutive titles at the Monte-Carlo Masters in the Open Era. The win also earned him his second Masters 1000 title and his eighth career singles title overall.
Former world No. 1 and eleven-time Monte-Carlo Masters champion Rafael Nadal did not compete due to a stress fracture in his rib. This marked the first edition of the tournament not to feature Nadal in the main draw since 2004.