2022 Italian Open – Women's singles
Defending champion Iga Świątek defeated Ons Jabeur in the final, 6–2, 6–2 to win the women's singles tennis title at the 2022 Italian Open. She did not drop a set during the tournament, and was the first player to win the title in Rome without dropping a set since Serena Williams in 2016. This was Świątek's fifth consecutive WTA Tour title, and she became the first player to win four WTA 1000 titles in a single season since Serena Williams in 2013. With the win, Świątek extended her winning streak to 28 matches – the longest on the WTA Tour since Serena Williams won 34 consecutive matches in 2013. This was also the first time in her professional career that Świątek defended a title. Jabeur was attempting to be the first player since Serena Williams in 2013 to win consecutive titles in Madrid and Rome; she reached the final after saving a match point in her semifinal match against Daria Kasatkina.
Seeds
The top eight seeds received a bye into the second round.Seeded players
The following are the seeded players, based on WTA rankings as of 25 April 2022. Rankings and points before are as of 9 May 2022.Because Rome is a non-mandatory event, but players must count, if played, at least two non-mandatory WTA 1000 tournaments on their rankings, points will be adjusted the following way:
- Players who have points from the 2021 tournament counting towards their ranking, will get those points replaced by:
- * The points from the 2022 tournament, if they have less than two non-mandatory WTA 1000 events or 16 total tournaments counting towards their ranking.
- * The points from the 2022 tournament or their 17th best result, whichever is higher, if they have at least two non-mandatory WTA 1000 events counting towards their ranking.
- Players who don't have points from the 2021 tournament counting towards their ranking, will have their ranking adjusted the following way:
- * The points from the 2022 tournament will be added to the players counting less than 16 tournaments towards their ranking.
- * The points from the 2022 tournament will replace the 16th best result of the players counting less than two non-mandatory WTA 1000 towards their ranking.
- * The points from the 2022 tournament, if higher, will replace the points from the worse non-mandatory WTA 1000 event or the 16th best result, whichever is lower, of the players counting two non-mandatory WTA 1000 events towards their ranking.
- * The points from the 2022 tournament, if higher, will replace the 16th best result of the players counting more than two non-mandatory WTA 1000 events towards their ranking.
| Seed | Rank | Player | Points before | Points defending † | Points won | Points after | Status | ||||
| 1 | 1 |  Withdrawn playersThe following player would have been seeded, but withdrew before the tournament began.
|
