2022 Guanajuato Open

The 2022 Guanajuato Open was a professional tennis tournament played on outdoor hard courts. It was the fourteenth edition of the tournament which was part of the 2022 ITF Women's World Tennis Tour. It took place in Irapuato, Mexico between 7 and 13 March 2022.

Singles main draw entrants

¹ Rankings are as of 28 February 2022.

The following players received wildcards into the singles main draw:

The following player received entry as a special exempt:

The following players received entry from the qualifying draw:

The following players received entry as lucky losers:

Zhu Lin def. Rebecca Marino, 6–4, 6–1

Kaitlyn Christian / Lidziya Marozava def. Anastasia Tikhonova / Daniela Vismane, 6–0, 6–2