2021–22 Serbian First League
The 2021–22 Serbian First League is the 17th season of the Serbian First League since its establishment.
League format
The league consist of 16 teams: eight teams from the 2020–21 Serbian First League, six teams relegated from 2020–21 Serbian SuperLiga and two new teams promoted from Serbian League.Teams
| Team | City | Stadium | Capacity |
| [FK FK Budućnost Dobanovci|Budućnost Dobanovci|Budućnost] | Belgrade | Stadion FK Budućnost | 1,000 |
| Grafičar | Belgrade | Topčiderska zvezda | 1,000 |
| IMT | Belgrade | Stadion FK IMT | 1,150 |
| Inđija | Inđija | Inđija Stadium | 4,500 |
| Javor Matis | Ivanjica | Javor Stadium | 3,000 |
| Kabel | Novi Sad | FK Kabel Stadium | 2,000 |
| Loznica | Loznica | Lagator Stadium | 5,000 |
| [FK FK Mačva Šabac|Mačva Šabac|Mačva] | Šabac | Mačva Stadium | 5,494 |
| Mladost GAT | Novi Sad | Stadion FK Mladost | 200 |
| OFK Bačka | Bačka Palanka | Stadion Slavko Maletin Vava | 4,000 |
| Žarkovo | Belgrade | Žarkovo Stadium | 610 |
| Rad | Belgrade | King Peter I Stadium | 3,919 |
| [FK FK Radnički Sremska Mitrovica|Radnički Sremska Mitrovica|Radnički] | Sremska Mitrovica | Stadion FK Radnički | 2,000 |
| Timok 1919 | Zaječar | Zaječar City Stadium | 10,000 |
| Železničar | Pančevo | SC Mladost | 1,200 |
| Zlatibor | Čajetina | Užice City Stadium | 15,000 |
Regular season
League table
Play-offs
Promotion round
The top eight teams advanced from the regular season. Teams played each other once.League table
Relegation round
The bottom eight teams from the regular season play in the relegation round. Teams play each other once.League table
Individual statistics
Top scorers
As of matches played on 22 May 2022.| Pos | Scorer | Teams | Goals |
| 1 |  Hat-tricks4 Player scored four goals |