2021 Andalucía Open

The 2021 Andalucía Open was a tournament on the 2021 ATP Tour. It was played on outdoor clay courts in Marbella, Spain. It was organised with a single-year licence in 2021, and was held at Club de Tennis Puente Romano from April 5 to 11, 2021.
It was the first edition of the AnyTech365 Andalucía Open, which became the fourth ATP Tour tournament in Spain, alongside competitions in Madrid, Barcelona and Mallorca. It was also the fourth edition of the Challenger 80 tournament held in Puente Romano in Marbella the week prior to the ATP 250 event.

Champions

Pablo Carreño Busta def. Jaume Munar, 6–1, 2–6, 6–4

Ariel Behar / Gonzalo Escobar def. Tomislav Brkić / Nikola Ćaćić, 6–2, 6–4

_{*per team}

The following players received wildcards into the main draw:

The following players received entry from the qualifying draw:

;Before the tournament

The following pairs received wildcards into the doubles main draw:

;Before the tournament