2021–22 Copa Argentina

The 2022 Copa Argentina was the twelfth edition of the Copa Argentina, and the tenth since the relaunch of the tournament in 2011. The competition began on 23 February and ended on 30 October 2022. Boca Juniors, the defending champions, were eliminated in the semi-finals.
Patronato defeated Talleres 1–0 in the final to win their first title in the tournament. As winners, they qualified for the 2023 Copa Libertadores group stage and earned the right to play against the winners of the 2022 Argentine Primera División in the 2022 Supercopa Argentina.

Teams

Sixty-four teams took part in this competition: All twenty-six teams from the Primera División; fifteen teams of the Primera Nacional; six from the Primera B, four from the Primera C; three from the Primera D and ten teams from Federal A.

First Level

Primera División

All twenty-six teams of the 2021 tournament qualified.

Second Level

Primera Nacional

The top seven teams of each zone and the best eighth-placed team of the 2021 tournament qualified.

Third Level

Primera B Metropolitana

The top six teams of the 2021 Primera B tournament qualified.

Torneo Federal A

The top five teams of each zone of the 2021 tournament qualified.

Fourth Level

Primera C Metropolitana

The top four teams of the 2021 Primera C tournament qualified.

Fifth Level

Primera D Metropolitana

The top-three teams of 2021 Primera D tournament qualified.

Final Rounds

Draw

The draw for the Final Rounds was held on 22 December 2021, 15:00 at AFA Futsal Stadium in Ezeiza. The 64 qualified teams were divided in four groups. Teams were seeded by their historical performance and Division. Champions of AFA tournaments playing in Argentine Primera División were allocated to Group A. The matches were drawn from the respective confronts: A vs. C; B vs. D. Some combinations were avoided for security reasons.

Group A	Group B	Group C	Group D
Argentinos Juniors Arsenal Banfield Boca Juniors Colón Estudiantes (LP) Gimnasia y Esgrima (LP) Huracán Independiente Lanús Newell's Old Boys Racing River Plate Rosario Central San Lorenzo Vélez Sarsfield	Aldosivi Almirante Brown Atlético Tucumán Barracas Central Central Córdoba (SdE) Defensa y Justicia Ferro Carril Oeste Godoy Cruz Independiente Rivadavia Patronato Platense Quilmes Sarmiento (J) Talleres (C) Tigre Unión	Central Córdoba (R) Central Norte (S) Chaco For Ever Cipolletti Defensores de Cambaceres Deportivo Madryn Dock Sud Gimnasia y Tiro Ituzaingó Laferrere Liniers Olimpo Puerto Nuevo Racing (C) Sol de Mayo Sportivo Las Parejas Sportivo Peñarol	Acassuso Agropecuario Argentino Belgrano Brown Colegiales Deportivo Morón Flandria Gimnasia y Esgrima (J) Gimnasia y Esgrima (M) Güemes (SdE) J. J. de Urquiza Los Andes Sacachispas San Martín (T) Tristán Suárez

Round of 64

The Round of 64 had 10 qualified teams from the Torneo Federal A, 13 qualified teams from the Metropolitan Zone, 15 teams from Primera Nacional and 26 teams from Primera División. The round was played between 23 February and 1 June 2022, in a single knock-out match format. The 32 winning teams advanced to the Round of 32.
;Notes

Round of 32

This round had 32 qualified teams from the Round of 64. The round was played between 8 June and 4 August 2022, in a single knock-out match format. The 16 winning teams advanced to the Round of 16.

Round of 16

This round had the 16 qualified teams from the Round of 32. The round was played between August 9 and September 15, in a single knock-out match format. The 8 winning teams advanced to the Quarterfinals.

Quarter-finals

This round had the 8 qualified teams from the Round of 16. The round was played between 27 and 28 September 2022, in a single knock-out match format. The 4 winning teams advanced to the semi-finals.

Semi-finals

This round had the 4 qualified teams from the Quarter-finals. The round was played on 26 October 2022, in a single knock-out match format. The 2 winning teams advanced to the Final.