2021–22 CAF Champions League
The 2021–22 CAF Champions League was the 58th season of Africa's premier club football tournament organized by the Confederation of African Football, and the 26th season under the current CAF Champions League title.
Wydad Casablanca won their 3rd title with a 2–0 win against the two-time defending champions, Al Ahly, in the final at Stade Mohammed V in Casablanca, Morocco, Wydad earned the right to play against RS Berkane, the winners of the 2021–22 CAF Confederation Cup, in the 2022 CAF Super Cup, As the first Super Cup to bring together two Moroccan clubs in history.
Association team allocation
A total of 42 out of the 56 CAF member associations entered this season's CAF Champions League, with the 12 highest ranked associations according to their CAF 5-year ranking eligible to enter two teams in the competition. For this season, the CAF utilized the 2017–2021 CAF 5-year ranking, which calculated points for each entrant association based on their clubs' performance over those 5 years in the CAF club competitions. The criteria for points were as follows:| CAF Champions League | CAF Confederation Cup | |
| Winners | 6 points | 5 points |
| Runners-up | 5 points | 4 points |
| Losing semi-finalists | 4 points | 3 points |
| Losing quarter-finalists | 3 points | 2 points |
| 3rd place in groups | 2 points | 1 point |
| 4th place in groups | 1 point | 0.5 point |
The points were multiplied by a coefficient according to the year as follows:
- 2020–21: x 5
- 2019–20: × 4
- 2018–19: × 3
- 2018: × 2
- 2017: × 1
Teams
The following 54 teams from 42 out of the total 54 member associations entered this season's tournament.- Teams in
- Bold received a bye to the [|second round].
- The other teams entered the [|first round].
; Associations which did not enter a team
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