2020 Copa Sudamericana second stage
The 2020 Copa Sudamericana second stage was played from 27 October to 5 November 2020. A total of 32 teams competed in the second stage to decide the 16 places in the final stages of the 2020 Copa Sudamericana.
The second stage had been originally scheduled to be played from 19 to 28 May 2020, but was postponed due to the COVID-19 pandemic.
Draw
The draw for the second stage was held on 23 October 2020, 12:00 PYT. For the second stage, the teams were allocated to two pots according to their previous results in this season:
- Pot 1: 10 teams transferred from the Copa Libertadores and six best winners of the first stage from the Copa Sudamericana
- Pot 2: 16 remaining winners of the first stage from the Copa Sudamericana
The following are the 10 teams transferred from the Copa Libertadores.
| Match | Best teams eliminated in third stage | Second stage draw |
| G3 | Atlético Tucumán | Pot 1 |
| G4 | Deportes Tolima | Pot 1 |
| Group | Third-placed teams in group stage | Second stage draw |
| A | Junior | Pot 1 |
| B | Bolívar | Pot 1 |
| C | Peñarol | Pot 1 |
| D | São Paulo | Pot 1 |
| E | Universidad Católica | Pot 1 |
| F | Estudiantes de Mérida | Pot 1 |
| G | Defensa y Justicia | Pot 1 |
| H | Caracas | Pot 1 |
The following are the 22 winners of the first stage from the Copa Sudamericana. Matches in the first stage were considered for the ranking of teams for the second stage draw.
Format
In the second stage, each tie was played on a home-and-away two-legged basis. If tied on aggregate, the away goals rule was used. If still tied, extra time was not played, and a penalty shoot-out was used to determine the winner.
The 16 winners of the second stage advanced to the round of 16 of the final stages.
Matches
The first legs were played on 27–29 October, and the second legs were played on 3–5 November 2020.Match O1
----''Independiente won 2–1 on aggregate and advanced to the round of 16.''
Match O2
----''Tied 2–2 on aggregate, Unión won on away goals and advanced to the round of 16.''
Match O3
----''Tied 1–1 on aggregate, Unión La Calera won on away goals and advanced to the round of 16.''
Match O4
----''Universidad Católica won 2–1 on aggregate and advanced to the round of 16.''
Match O5
----''Tied 3–3 on aggregate, Deportivo Cali won on penalties and advanced to the round of 16.''
Match O6
----''Sport Huancayo won 3–2 on aggregate and advanced to the round of 16.''
Match O7
----''Vasco da Gama won 1–0 on aggregate and advanced to the round of 16.''
Match O8
----''Tied 6–6 on aggregate, Lanús won on away goals and advanced to the round of 16.''
Match O9
----''Bolívar won 4–2 on aggregate and advanced to the round of 16.''
Match O10
----''Defensa y Justicia won 3–2 on aggregate and advanced to the round of 16.''
Match O11
----''Coquimbo Unido won 5–0 on aggregate and advanced to the round of 16.''
Match O12
----''Tied 1–1 on aggregate, Vélez Sarsfield won on away goals and advanced to the round of 16.''
Match O13
----''River Plate won 4–2 on aggregate and advanced to the round of 16.''
Match O14
----''Junior won 1–0 on aggregate and advanced to the round of 16.''
Match O15
----''Bahia won 4–1 on aggregate and advanced to the round of 16.''
Match O16
----''Fénix won 4–2 on aggregate and advanced to the round of 16.''