2019 US Open – Men's singles
Rafael Nadal defeated Daniil Medvedev in the final, 7–5, 6–3, 5–7, 4–6, 6–4 to win the men's singles tennis title at the [2019 US Open (tennis)|US Open (tennis)|2019 US Open]. It was his fourth US Open title and 19th major title overall. Nadal's victory meant that every major title since the beginning of 2017 had been won by either himself, Novak Djokovic or Roger Federer. This was the first time since 2006–08 that Djokovic, Federer, and Nadal had claimed all four major singles titles across three consecutive years.
Djokovic was the defending champion, but retired due to a left shoulder injury against Stan Wawrinka in the fourth round. This was the first time since 2006 that Djokovic failed to reach the US Open semifinals.
Medvedev was the second Russian player to reach the final, and the first Russian man to reach a major final since Safin at the 2005 Australian Open.
Grigor Dimitrov was the lowest-ranked US Open men's semifinalist since Jimmy Connors in 1991, and the lowest-ranked men's singles semifinalist at any major since Rainer Schüttler at the 2008 Wimbledon Championships. This was the first time in the Open Era that four quarterfinalists were 33 years old or older.
This marked the first major main-draw appearance for future major champion and world No. 1 Jannik Sinner; he lost to Wawrinka in the first round. This was the final US Open appearance of five-time champion Federer; he lost in the quarterfinals to Dimitrov. This was also the final professional appearance of former world No. 4 and 2010 Wimbledon finalist Tomáš Berdych, who lost in the first round to Jenson Brooksby.