| Round | Date | Opponent | Result | Score | Home/Away | Venue | Tries | Goals | Attendance | TV |
| 1 | 12 February 2011 | Huddersfield Giants | Lost | | Away | Millennium Stadium | J. Monaghan, Atkins, Westwood | Hodgson | 30,891 | SKY |
| 2 | 20 February 2011 | Hull Kingston Rovers | Won | | Home | Halliwell Jones Stadium | Riley, Myler, Atkins, J. Monaghan, Hodgson | Hodgson | 10,899 | |
| 3 | 25 February 2011 | St. Helens | Won | | Away | Halton Stadium | Briers, Myler, Anderson | Hodgson, DG Briers | 10,514 | SKY |
| 4 | 5 March 2011 | Leeds Rhinos | Won | | Home | Halliwell Jones Stadium | R.Evans, Myler, Briers, J. Monaghan, Grix, Riley, Higham, | Hodgson | 11,438 | SKY |
| 5 | 11 March 2011 | Wakefield Trinity Wildcats | Won | | Away | Belle Vue | Riley, Bridge, Atkins, Myler | Westwood | 5,072 | SKY |
| 6 | 20 March 2011 | Harlequins RL | Won | | Home | Halliwell Jones Stadium | Bridge, Myler, Hodgson, Blythe, R.Evans, Briers, Westwood, Morley, Solomona, Mitchell | Hodgson | 11,506 | |
| 7 | 25 March 2011 | Wigan Warriors | Won | | Away | DW Stadium | Blythe, J.Monaghan, Myler | Hodgson | 21,056 | SKY |
| 8 | 3 April 2011 | Catalans Dragons | Lost | | Home | Halliwell Jones Stadium | J. Monaghan (2), Riley, Myler | Hodgson | 10,056 | |
| 9 | 8 April 2011 | Huddersfield Giants | Lost | | Away | Galpharm Stadium | Hodgson | Hodgson | 7,224 | SKY |
| 10 | 15 April 2011 | Crusaders | Won | | Home | Halliwell Jones Stadium | Hodgson, Westwood, Williams, Anderson, Atkins, Bridge, J. Monaghan, Myler | Hodgson | 10,002 | |
| 11 | 22 April 2011 | Salford City Reds | Won | | Away | The Willows | Atkins, Myler, Briers, Bridge, Carvell, J. Monaghan, Williams, Wood | Hodgson | 7,496 | |
| 12 | 25 April 2011 | Hull F.C. | Lost | | Home | Halliwell Jones Stadium | J.Monaghan, Williams | Hodgson | 12,036 | |
| 13 | 1 May 2011 | Bradford Bulls | Won | | Away | Grattan Stadium | Anderson, Atkins, M.Monaghan, J.Monaghan, King, Hodgson, Bridge, Higham, Briers | Hodgson | 14,134 | |
| 14 | 13 May 2011 | Castleford Tigers | Won | | Home | Halliwell Jones Stadium | O'Brien, Briers, King, Hodgson, Grix, Higham, Solomona, J.Monaghan | Hodgson, Briers | 9,958 | SKY |
| 15 | 27 May 2011 | Leeds Rhinos | Won | | Away | Headingley Carnegie Stadium | Briers, J.Monaghan, Solomona, King, Bridge, M.Monaghan | Hodgson | 17,276 | SKY |
| 16 | 3 June 2011 | Crusaders | Won | | Away | Racecourse Ground, Wrexham | Hodgson, Wood, King, Morley, Westwood, Atkins, Myler | Hodgson | 4,907 | |
| 17 | 12 June 2011 | Salford City Reds | Lost | | Home | Halliwell Jones Stadium | Bridge, Briers, Myler | Hodgson | 10,339 | |
| 18 | 19 June 2011 | Hull Kingston Rovers | Won | | Away | Craven Park | Grix, King, Atkins, Briers, Williams, Myler | Hodgson | 8,143 | |
| 19 | 24 June 2011 | St. Helens | Won | | Home | Halliwell Jones Stadium | M.Monaghan, Williams, King, Wood, Westwood, Hodgson | Hodgson | 13,024 | SKY3D |
| 20 | 1 July 2011 | Castleford Tigers | Won | | Away | The Probiz Coliseum | King, Hodgson, Myler, Blythe, J. Monaghan, Atkins | Hodgson | 5,947 | |
| 21 | 8 July 2011 | Huddersfield Giants | Won | | Home | Halliwell Jones Stadium | Hodgson, J.Monaghan, Myler, Anderson | Hodgson | 10,283 | SKY3D |
| 22 | 16 July 2011 | Harlequins RL | Won | | Away | The Stoop | Bridge, Carvell, J.Monaghan, Briers, Myler, Wood | Hodsgon, Briers | 3,842 | |
| 23 | 31 July 2011 | Bradford Bulls | Won | | Home | Halliwell Jones Stadium | Atkins, King, Anderson, J.Monaghan, Myler, Cooper, Bridge | Bridge, Hodgson | 10,641 | |
| 24 | 14 August 2011 | Wakefield Trinity Wildcats | Won | | Home | Halliwell Jones Stadium | Atkins, King, J.Monaghan, M.Monaghan, Hodgson | Hodgson, Bridge | 10,641 | |
| 25 | 20 August 2011 | Catalans Dragons | Won | | Away | Stade Aime Giral | Bridge, Atkins, Briers | Bridge, DG Briers | 9,495 | |
| 26 | 4 September 2011 | Wigan Warriors | Won | | Home | Halliwell Jones Stadium | M.Monaghan, J.Monaghan, King, Briers, Clarke | Bridge, DG M.Monaghan | 13,024 | SKY |
| 27 | 9 September 2011 | Hull F.C. | Won | | Away | KC Stadium | Atkins, Riley, M.Monaghan, Bridge, J.Monaghan | Bridge, Briers | 10,845 | SKY |