| 49 | Philadelphia Union | 
Trade note- Los Angeles Galaxy traded the rights to American midfielder/forward Clint Mathis to Real Salt Lake on 2008-08-14. It was reported that LA would receive a conditional fourth-round pick in the 2010 SuperDraft from RSL in exchange. However, RSL kept its fourth-round 2010 selection and instead sent its natural third-round selection in the 2011 MLS SuperDraft to Los Angeles to complete the deal.
In December 2008 the league decided to cancel the Supplemental Draft, which had typically been held shortly after the annual SuperDraft. Prior to the cancellation a few trades were made involving 2010 Supplemental Draft picks. It is unknown what compensation, if any, clubs trading for 2010 Supplemental Draft picks received in lieu of the draft picks. Announced trades involving 2010 Supplemental Draft selections include:Round 4, San Jose Earthquakes → Chicago Fire. 2008-04-04: Chicago Fire acquired a fourth-round selection in the 2010 Supplemental Draft from San Jose Earthquakes in exchange for forward Ryan Johnson. It is likely that Chicago instead received San Jose's fourth-round pick in the 2010 SuperDraft to fulfill this trade as no trade was announced between the two clubs which involved a fourth-round 2010 SuperDraft pick.Round 4, D.C. United → Houston Dynamo. 2008-06-30: Houston Dynamo acquired a fourth-round selection in the 2010 Supplemental Draft from D.C. United in exchange for midfielder Craig Thompson.Conditional, Los Angeles Galaxy → San Jose Earthquakes. 2008-11-24: San Jose Earthquakes acquired a conditional selection in the 2010 Supplemental Draft from Los Angeles Galaxy in exchange for forward Jovan Kirovski.
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