2006 CFL draft
The 2006 CFL draft took place on Thursday, April 20, 2006. 50 players were chosen from among eligible players from Canadian Universities across the country, as well as Canadian players playing in the NCAA. Trades that occurred with the now defunct Ottawa Renegades were still valid, adding picks to both the second and fourth rounds, but any selections that were still held by the Renegades were justly skipped. Of the 50 draft selections, 26 players were drafted from Canadian Interuniversity Sport institutions.Round one
Round two
| Pick # | CFL team | Player | Position | School |
| 9 | Hamilton Tiger-Cats | Jermaine Reid | DL | Akron |
| 10 | Toronto Argonauts | Leron Mitchell | DB | Western Ontario |
| 11 | Hamilton Tiger-Cats | Peter Dyakowski | OL | Louisiana State |
| 12 | Saskatchewan Roughriders | Luca Congi | K | Simon Fraser |
| 13 | Calgary Stampeders | Jon Cornish | RB | Kansas |
| 14 | Toronto Argonauts | Aaron Wagner | LB | Brigham Young |
| 15 | BC Lions | Jon Hameister-Ries | OL | Tulsa |
| 16 | Montreal Alouettes | Etienne Boulay | DB | New Hampshire |
| 17 | Edmonton Eskimos | Jason Nugent | DB | Rutgers |
Round three
| Pick # | CFL team | Player | Position | School |
| 18 | Hamilton Tiger-Cats | Shawn Mayne | DE | Connecticut |
| 19 | Winnipeg Blue Bombers | Arjei Franklin | WR | Windsor |
| 20 | Saskatchewan Roughriders | Chris Cowan | OL | Saint Mary's |
| 21 | Edmonton Eskimos | Dwayne Mundle | LB | West Virginia |
| 22 | Saskatchewan Roughriders | Tristan Clovis | LB | McMaster |
| 23 | Winnipeg Blue Bombers | Dominic Picard | OL | Laval |
| 24 | Montreal Alouettes | Jeff Perrett | OT | Tulsa |
| 25 | Edmonton Eskimos | Mike Williams | DE | Boise State |
Round four
Round five
Round six