2005–06 Cuban National Series
The 45th season of the Cuban National Series ended with another title for Industriales. Though the Lions failed to win their division, they won close-fought series throughout the playoffs and won their 11th championship.
Regular season standings
West
| Team | W | L | PCT. | GB |
| Sancti Spíritus | 58 | 32 | .644 | - |
| Industriales | 56 | 34 | .622 | 2 |
| Havana Province | 51 | 38 | .573 | 6½ |
| Cienfuegos | 35 | 54 | .393 | 22½ |
East
| Team | W | L | PCT. | GB |
| Santiago de Cuba | 56 | 34 | .622 | - |
| Granma | 51 | 38 | .573 | 4½ |
| Guantánamo | 34 | 56 | .378 | 22 |
| Holguín | 27 | 63 | .300 | 29 |