2005–06 UEFA Champions League knockout stage
The knockout stage of the 2005–06 UEFA Champions League featured the 16 teams who finished in the top two positions in each of the eight groups in the group stage. It was played as a single-elimination tournament, with ties in the round of 16, quarter-finals and semi-finals played over two legs. The first matches of the round of 16 were played on 21 February 2006 and the final was played on 17 May 2006 at the Stade de France in Saint-Denis, near Paris, France.
Qualified teams
| Group | Winners | Runners-up |
| A | Juventus | Bayern Munich |
| B | Arsenal | Ajax |
| C | Barcelona | Werder Bremen |
| D | Villarreal | Benfica |
| E | Milan | PSV Eindhoven |
| F | Lyon | Real Madrid |
| G | Liverpool | Chelsea |
| H | Internazionale | Rangers |
Round of 16
Summary
Matches
Barcelona won 3–2 on aggregate.----
Arsenal won 1–0 on aggregate.
----
4–4 on aggregate; Juventus won on away goals.
----
Milan won 5–2 on aggregate.
----
Lyon won 5–0 on aggregate.
----
Internazionale won 3–2 on aggregate.
----
Benfica won 3–0 on aggregate.
----
''3–3 on aggregate; Villarreal won on away goals.''
Quarter-finals
Summary
Matches
Arsenal won 2–0 on aggregate.----
Milan won 3–1 on aggregate.
----
2–2 on aggregate; Villarreal won on away goals.
----
''Barcelona won 2–0 on aggregate.''
Semi-finals
Summary
Matches
Arsenal won 1–0 on aggregate.----
''Barcelona won 1–0 on aggregate.''
Final
The final was played on 17 May 2006 at the Stade de France in Saint-Denis, France.