2000–01 UEFA Cup second round

The second round of the 2000–01 UEFA Cup began on 23 October 2000. The round included 48 winners from the first round.

Teams

The following 48 teams participated in the second round.

Key to colours

Winners of second round advanced to third round

Seeding

UEFA allocated the teams into four groups, each with six seeded and six unseeded teams.

Summary

Matches

1. FC Kaiserslautern won 5–4 on aggregate.
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Osijek won 4–1 on aggregate.
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PAOK won 3–1 on aggregate.
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Werder Bremen won 9–3 on aggregate.
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1860 Munich won 5–4 on aggregate.
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AEK Athens won 6–2 on aggregate.
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Hertha BSC won 4–2 on aggregate.
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Alavés won 5–3 on aggregate.
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1–1 on aggregate; Internazionale won on away goals.
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Bordeaux won 3–2 on aggregate.
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Espanyol won 4–1 on aggregate.
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Roma won 2–1 on aggregate.
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VfB Stuttgart won 3–2 on aggregate.
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Celta Vigo won 3–1 on aggregate.
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Lokomotiv Moscow won 3–1 on aggregate.
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Feyenoord won 3–1 on aggregate.
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Liverpool won 4–2 on aggregate.
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2–2 on aggregate; Rayo Vallecano won on away goals.
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Lausanne-Sports won 3–2 on aggregate.
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Nantes won 3–1 on aggregate.
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Club Brugge won 3–2 on aggregate.
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Parma won 2–1 on aggregate.
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Slavia Prague won 6–3 on aggregate.
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''Porto won 3–0 on aggregate.''