2,3-Dimethoxyamphetamine
2,3-Dimethoxyamphetamine, also known as DMA-2, is a drug of the phenethylamine and amphetamine families. It is one of the positional isomers of dimethoxyamphetamine.
The drug showed weak affinity for serotonin receptors in rat stomach fundus strips. In a subsequent study, 2,3-DMA showed very low affinity for the serotonin 5-HT2A and 5-HT2C receptors. It did not show activity as a norepinephrine releasing agent in vitro. The drug is behaviorally active in mice. 2,3-DMA did not substitute for DOM in rodent drug discrimination tests. However, it did partially substitute for 5-MeO-DMT in these tests. As with DOM, the drug did not substitute for dextroamphetamine in drug discrimination tests. It produced behavioral disruption at higher doses. 2,3-DMA does not appear to have been tested in humans.
2,3-DMA was first described in the scientific literature by 1968. Alexander Shulgin first described 2,3-DMA in 1969 but had not yet synthesized it and did not report its effects.