1980–81 FA Vase
The 1980–81 FA Vase was the seventh season of the FA Vase, an annual football competition for teams in the lower reaches of the English football league system.
Whickham, of Tyne and Wear, won the competition, beating Willenhall Town in the final.
Third round
| Home team | Score | Away team |
| Sawbridgeworth Town | 1–2 | Kempston Rovers |
| Home team | Score | Away team |
| Lincoln United | 3–4 | Wigston Fields |
Fourth round
Fifth round
| Home team | Score | Away team |
| Whickham | 2–0 | Thackley |
| Guiseley | 2–0 | Hallam |
| Willenhall Town | 2–0 | Middlewich Athletic |
| Alma Swanley | 2–0 | Coventry Sporting |
| Home team | Score | Away team |
| Hungerford Town | 0–1 | Windsor & Eton |
| Whyteleafe | 1–2 | Basildon United |
| Devizes Town | 2–1 | Kempston Rovers |
| Cray Wanderers | 0–0 | Irthlingborough Diamonds |
Quarter-finals
| Home team | Score | Away team |
| Basildon United | 0–0 | Irthlingborough Diamonds |
| Whickham | 3–0 | Devizes Town |
| Home team | Score | Away team |
| Alma Swanley | 2–2 | Windsor & Eton |
| Guiseley | 2–4 | Willenhall Town |
Replays
| Home team | Score | Away team |
| Irthlingborough Diamonds | 6–4 | Basildon United |
| Home team | Score | Away team |
| Windsor & Eton | 4–1 | Alma Swanley |
Semi-finals
| Leg no | Home team | Score | Away team |
| 1st | Windsor & Eton | 1–1 | Whickham |
| 2nd | Whickham | 1–0 | Windsor & Eton |
Whickham won 2-1 on aggregate.
| Leg no | Home team | Score | Away team |
| 1st | Irthlingborough Diamonds | 1–1 | Willenhall Town |
| 2nd | Willenhall Town | 2–0 | Irthlingborough Diamonds |
''Willenhall Town won 3–1 on aggregate.''