1978 Campeonato Nacional Primera División

The 1978 Campeonato Nacional was Chilean first tier's 46th season. Palestino was the tournament's champion, winning its second title.

Liguilla Pre-Copa Libertadores

----
----

Liguilla play-off match

O'Higgins qualified to 1979 Copa Libertadores due to its better League position

Promotion/relegation Liguilla

* There was no promotion or relegation.