| Old Number | Southern or western terminus | Northern or eastern terminus | Length, km | New Number/s | Notes |
| Route 1 | Barrio Playa in Ponce | La Fortaleza in San Juan | | PR-123, PR-14, PR-1, PR-25 | Carretera Central. Parts of PR-14R, PR-735, PR-798, PR-8834, PR-873 and PR-8838 belong to original segments of this highway. |
| Route 2 | Route 6 in Ponce | Route 1 in San Juan | | PR-132, PR-2, PR-115, PR-23, PR-1, PR-39 | Parts of PR-127, PR-121, PR-102, PR-114, PR-239, PR-104, PR-439, PR-4439, PR-1107, PR-460, PR-469, PR-112, PR-113, PR-479, PR-484, PR-4491, PR-119, PR-4490, PR-660, PR-681, PR-6681, PR-662, PR-669, PR-670, PR-155, PR-160, PR-676, PR-680, PR-165, PR-8865, PR-864, PR-855, PR-41 and PR-42 belong to original segments of this highway. |
| Route 3 | Route 1 in Ponce | Route 1 in San Juan | | PR-133, PR-1, PR-3 | Parts of PR-578, PR-5507, PR-178, PR-182, PR-9910, PR-979, PR-194, PR-940, PR-193, PR-955, PR-187, PR-187R, PR-958, PR-9958, PR-9959, PR-874, PR-887 and PR-47 belong to original segments of this highway. |
| Route 4 | Route 3 in Guayama | Route 1 in Cayey | | PR-15 | |
| Route 5 | Route 22 in Comerío | Route 3 in Humacao | — | PR-156, PR-189, PR-198 | PR-7156 and PR-768 belong to original segments of this highway. |
| Route 6 | Route 1 in Ponce | Route 2 in Arecibo | | PR-123, PR-10 | PR-6609 and PR-6109 belong to an original segment of this highway. |
| Route 7 | Route 1 in Caguas | Route 5 in Las Piedras | | PR-183 | Parts of PR-9931, PR-181 and PR-980 belong to original segments of this highway. |
| Route 8 | Route 2 in Aguadilla | Route 6 in Adjuntas | | PR-111, PR-128, PR-135 | Parts of PR-1107, PR-4443, PR-125, PR-125R, PR-4111 and PR-1111 belong to original segments of this highway. |
| Route 9 | Route 15 in Barranquitas | Route 2 in Bayamón | | PR-156, PR-167 | PR-839 belongs to an original segment of this highway. |
| Route 10 | Route 1 in Coamo | Route 2 in Dorado | — | PR-155, PR-568, PR-159, PR-165 | Parts of PR-5155, PR-891 and PR-165R belong to original segments of this highway. |
| Route 11 | Route 1 in Juana Díaz | Route 2 in Manatí | | PR-149 | Parts of PR-570, PR-519, PR-5550, PR-550, PR-589, PR-149R, PR-146 and PR-6685 belong to original segments of this highway. |
| Route 12 | Route 3 in Patillas | Route 7 in San Lorenzo | — | PR-181 | Part of PR-183 belongs to an original segment of this highway. |
| Route 13 | Route 8 in Lares | Route 2 in Arecibo | | PR-111, PR-129 | Parts of PR-1111 and PR-134 belong to original segments of this highway. |
| Route 14 | Route 35 in Mayagüez | Route 16 in Maricao | — | PR-106, PR-120, PR-105 | |
| Route 15 | Route 6 in Adjuntas | Route 1 in Aibonito | | PR-143, PR-140, PR-144, PR-141, PR-533, PR-157, PR-155, PR-156, PR-162 | The northern part of PR-5155 belongs to an original segment of this highway. This road was briefly interrupted by Route 11 in Ciales. |
| Route 16 | Route 2 in Yauco | Route 8 in Lares | | PR-128 | Parts of PR-375, PR-371 and PR-3372 belong to an original segment of this highway. |
| Route 17 | Route 13 in Lares | Route 15 in Jayuya | — | PR-111, PR-140 | PR-6111 belongs to an original segment of this highway. This road was briefly interrupted by Route 6 in Utuado. |
| Route 18 | Route 19 in Cabo Rojo | Route 2 in Cabo Rojo | | PR-307, PR-308, PR-103, PR-102 | |
| Route 19 | Barrio Boquerón in Cabo Rojo | Route 39 in Lajas | | PR-101 | |
| Route 20 | Route 11 in Ciales | Route 9 in Naranjito | | PR-633, PR-155, PR-159, PR-164 | Parts of PR-6633 and PR-149 belong to an original segment of this highway. This road was interrupted by Route 10 into two segments: one from Ciales to western Corozal and the other from eastern Corozal to Naranjito. |
| Route 21 | Baños de Coamo in Coamo | Route 1 in Coamo | | PR-546, PR-153 | |
| Route 22 | Route 9 in Comerío | Route 1 in Cidra | | PR-172, PR-787 | Part of PR-7167, PR-781 and PR-156 belong to an original segment of this highway. |
| Route 23 | Route 5 in Gurabo | Route 3 in San Juan | — | PR-181 | PR-943, PR-876 and PR-877 belong to original segments of this highway. |
| Route 24 | Route 2 in Bayamón | Barrio Pueblo in Cataño | | PR-5 | PR-890 belongs to an original segment of this highway. |
| Route 25 | Route 1 in Guaynabo | Route 24 in Cataño | | PR-20, PR-165 | PR-169, PR-19 and PR-24 belong to original segments of this highway. This road was briefly interrupted by Route 2 in San Patricio area. |
| Route 26 | Route 17 in Utuado | Route 2 in Barceloneta | — | PR-140 | |
| Route 27 | Route 2 in Mayagüez | Route 14 in Maricao | | PR-105 | |
| Route 28 | Route 5 in Juncos | Route 3 in Naguabo | | PR-31, PR-192 | |
| Route 29 | Route 18 in Cabo Rojo | Route 2 in San Germán | | PR-102, PR-317 | |
| Route 30 | Route 20 in Morovis | Route 2 in Vega Baja | | PR-155 | |
| Route 31 | Route 1 in Aibonito | Route 9 in Comerío | — | PR-173, PR-775, PR-740 | Part of PR-727 belongs to an original segment of this highway. |
| Route 32 | Route 3 in San Juan | Route 1 in San Juan | — | PR-27, PR-36 | |
| Route 33 | Route 13 in Hatillo | Route 2 in Hatillo | — | PR-130 | |
| Route 34 | Route 8 in San Sebastián | Route 2 in Camuy | — | PR-119 | |
| Route 35 | Route 2 in Mayagüez | Route 8 in San Sebastián | | PR-106, PR-119 | Formerly portion of Route 13 |
| Route 36 | Route 2 in Guayanilla | Route 2 in Ponce | | PR-127, PR-2, PR-2R | PR-591 and PR-5549 belong to original segments of this highway. |
| Route 37 | Route 18 in Cabo Rojo | Route 2 in Mayagüez | — | PR-102 | |
| Route 38 | Route 69 in Vieques | Barrio Puerto Diablo in Vieques | — | PR-200 | |
| Route 39 | Route 2 in San Germán | Route 2 in Yauco | | PR-101, PR-116 | PR-320, PR-315, PR-3116, PR-4116 and PR-326 belong to original segments of this highway. |
| Route 40 | Route 2 in Añasco | Route 8 in San Sebastián | — | PR-109 | |
| Route 41 | Route 1 in San Juan | Route 1 in San Juan | | PR-35 | Part of PR-1 and PR-16 belong to an original segment of this highway. |
| Route 42 | Route 10 in Toa Alta | Route 9 in Bayamón | | PR-861 | |
| Route 43 | Route 5 in Juncos | Route 3 in Canóvanas | — | PR-185 | PR-952 belongs to an original segment of this highway. |
| Route 44 | Route 3 in Canóvanas | Route 3 in Río Grande | — | PR-951, PR-187 | |
| Route 45 | Route 46 in San Juan | Route 2 in San Juan | — | PR-18, PR-41 | |
| Route 46 | Route 25 in San Juan | Route 1 in San Juan | | PR-21 | |
| Route 47 | Route 3 in Salinas | Route 1 in Cayey | — | PR-1, PR-170 | |
| Route 48 | Route 47 in Aibonito | Route 1 in Aibonito | — | PR-162 | |
| Route 49 | Route 1 in Cayey | Route 22 in Cidra | — | PR-171 | PR-7731 belongs to an original segment of this highway. |
| Route 50 | Route 2 in Mayagüez | Route 2 in San Germán | — | PR-348, PR-119 | Parts of PR-2, PR-360 and PR-347 belong to an original segment of this highway. |
| Route 51 | Route 1 in Ponce | Route 15 in Jayuya | — | PR-139, PR-143 | PR-139R belongs to an original segment of this highway. |
| Route 52 | Route 2 in Toa Baja | Playa de Sardinera in Dorado | — | PR-165, PR-6165, PR-693, PR-697 | PR-854 belongs to an original segment of this highway. |
| Route 53 | Route 2 in Dorado | Route 52 in Dorado | — | PR-693 | |
| Route 54 | Route 20 in Morovis | Route 2 in Vega Baja | — | PR-160 | |
| Route 55 | Route 2 in Arecibo | Route 96 in Barceloneta | — | PR-681 | - |
| Route 56 | Route 39 in Lajas | Route 2 in Sabana Grande | — | PR-117 | |
| Route 57 | Route 3 in Carolina | Route 1 in San Juan | — | PR-26 | Parts of PR-8887, PR-190 and PR-37 belong to original segments of this highway. |
| Route 58 | Route 43 in Carolina | Route 3 in Carolina | — | PR-853 | |
| Route 60 | Route 3 in Ceiba | [Machos, Ceiba, Puerto Rico|Ceiba, Puerto Rico|Barrio Machos] in Ceiba | — | Formerly PR-980 | Roosevelt Roads Naval Station |
| Route 61 | Route 3 in Juana Díaz | Route 1 in Juana Díaz | | PR-149 | PR-592 belongs to an original segment of this highway. |
| Route 62 | Route 4 in Guayama | Route 1 in Cidra | — | PR-179, PR-184 | PR-7736 belongs to an original segment of this highway. |
| Route 63 | Route 5 in Aguas Buenas | Route 2 in Bayamón | — | PR-174 | Part of PR-5 belongs to an original segment of this highway. |
| Route 64 | Route 8 in Adjuntas | Route 13 in Lares | — | PR-129 | |
| Route 65 | Route 11 in Villalba | Route 10 in Orocovis | — | PR-150, PR-151, PR-143 | |
| Route 67 | Route 23 in Trujillo Alto | Route 23 in Trujillo Alto | — | PR-175, PR-846 | |
| Route 68 | Route 34 in Camuy | Route 2 in Quebradillas | — | PR-113 | |
| Route 69 | Route 38 in Vieques | Route 38 in Vieques | — | PR-201 | |
| Route 70 | Barrio Punta Arenas in Vieques | Route 38 in Vieques | — | PR-200 | |
| Route 73 | Route 2 in Añasco | Route 40 in Añasco | — | PR-402 | |
| Route 75 | Route 11 in Manatí | Route 30 in Vega Baja | — | PR-643 | |
| Route 77 | Route 3 in Santa Isabel | Route 21 in Coamo | — | PR-153 | |
| Route 78 | Route 2 in Hormigueros | Route 50 in Mayagüez | — | PR-309, PR-344 | |
| Route 80 | Route 2 in Peñuelas | Route 8 in Adjuntas | — | PR-386, PR-131 | This road was interrupted between Peñuelas and Adjuntas. |
| Route 81 | Route 2 in Sabana Grande | Route 27 in Maricao | — | PR-120 | |
| Route 82 | Route 2 in Hormigueros | Route 2 in Hormigueros | — | PR-319, PR-309, PR-343 | |
| Route 85 | Route 35 in Mayagüez | Route 40 in Añasco | — | PR-108 | |
| Route 92 | Route 35 in Las Marías | [Buena Vista, Las Marías, Puerto Rico|Las Marías, Puerto Rico|Barrio Buena Vista] in Las Marías | — | PR-124, PR-370 | |
| Route 93 | Route 92 in Las Marías | Route 8 in Lares | — | PR-124 | |
| Route 96 | Route 2 in Barceloneta | Route 2 in Barceloneta | — | PR-140 | PR-6140 belongs to an original segment of this highway. |
| Route 98 | Cerro Maravilla in Ponce | Route 11 in Orocovis | — | PR-577, PR-143 | |
| Route 100 | Route 15 in Orocovis | Route 20 in Morovis | — | PR-155 | |
| Route 102 | Route 10 in Orocovis | Route 15 in Barranquitas | — | PR-143, PR-720 | |
| Route 103 | Route 11 in Villalba | Route 10 in Coamo | — | PR-150 | |
| Route 104 | Route 77 in Coamo | Route 47 in Salinas | — | PR-154 | |
| Route 107 | Route 31 in Cidra | Route 22 in Cidra | — | PR-173 | |
| Route 109 | Route 5 in Aguas Buenas | Route 1 in Guaynabo | — | PR-173 | |
| Route 110 | Route 1 in Caguas | Route 67 in Trujillo Alto | — | PR-175 | |
| Route 111 | Route 7 in San Lorenzo | Route 5 in Gurabo | — | PR-181 | |
| Route 112 | Route 28 in Naguabo | Route 3 in Río Grande | — | PR-191 | El Yunque National Forest |