T cell deficiency
T cell deficiency is a deficiency of T cells, caused by decreased function of individual T cells, it causes an immunodeficiency of cell-mediated immunity. T cells normal function is to help with the human body's immunity, they are one of the two primary types of lymphocytes.
Symptoms and signs
Presentations differ among causes, but T cell insufficiency generally manifests as unusually severe common viral infections, diarrhea, and eczematous or erythrodermatous rashes. Failure to thrive and cachexia are later signs of a T-cell deficiency.Mechanism
In terms of the normal mechanism of T cell we find that it is a type of white blood cell that has an important role in immunity, and is made from thymocytes. One sees in the partial disorder of T cells that happen due to cell signaling defects, are usually caused by hypomorphic gene defects. Generally, deletion of 22Q11.2 is the most often seen.Pathogens of concern
The main pathogens of concern in T cell deficiencies are intracellular pathogens, including Herpes simplex virus, Mycobacterium and Listeria. Also, intracellular fungal infections are also more common and severe in T cell deficiencies. Other intracellular pathogens of major concern in T cell deficiency are:Diagnosis
The diagnosis of T cell deficiency can be ascertained in those individuals with this condition via the following:- Delayed hypersensitivity skin test
- T cell count
- Detection via culture
Types
Primary or secondary
- Primary immunodeficiencies of T cells include some that cause complete insufficiency of T cells, such as severe combined immunodeficiency, Omenn syndrome, and Cartilage–hair hypoplasia.
- Secondary causes are more common than primary ones. Secondary causes are mainly:
Complete or partial deficiency
- Complete insufficiency of T cell function can result from hereditary conditions such as severe combined immunodeficiency, Omenn syndrome, and cartilage–hair hypoplasia.
- Partial insufficiencies of T cell function include acquired immune deficiency syndrome, and hereditary conditions such as DiGeorge syndrome, chromosomal breakage syndromes, and B-cell and T-cell combined disorders such as ataxia-telangiectasia and Wiskott–Aldrich syndrome.
Recognition of T cell deficiency
- Recognition of T cell disorders can involve identifying deficiencies in MHC class I or class II molecules. MHC class I and MHC class II molecules are cell-surface proteins that facilitate immune recognition by displaying peptide antigens to T lymphocytes. MHC class I presents peptides derived from intracellular proteins to CD8⁺ cytotoxic T cells, while MHC class II presents peptides originating from extracellular sources to CD4⁺ helper T cells. This antigen presentation allows the immune system to distinguish normal cells from those that are infected or otherwise altered, enabling an appropriate and targeted immune response. A deficiency in MHC class I interferes with the maturation of cytotoxic T cells, which rely on MHC I for proper development, leading to a deficiency of these cells. Without functional MHC I, CD8+ T cells cannot effectively destroy virus-infected or abnormal cells. Similarly, MHC class II deficiency disrupts helper T cell maturation, leading to T cell deficiency, impaired activation of other immune cells, and a weakened immune response.
Treatment
- Killed vaccines should be used
- Bone marrow transplant
- Immunoglobulin replacement
- Antiviral therapy
- Supplemental nutrition
Epidemiology
Furthermore, SCID has an incidence of approximately 1 in 66,000 in California.