Neuroprostanes
The neuroprostanes are prostaglandin-like compounds formed in vivo from the free radical-catalyzed peroxidation
of essential [fatty acid]s without the direct action of cyclooxygenase enzymes. The result is the formation of isoprostane-like compounds F4-, D4-, E4-, A4-, and J4-neuroprostanes which have been shown to be produced in vivo. These oxygenated essential fatty acids possess potent biological activity as anti-inflammatory mediators inhibiting the response of human macrophages that augment the perception of pain.