The Global Fund to Fight AIDS, Tuberculosis and Malaria
The Global Fund, officially The Global Fund to Fight AIDS, Tuberculosis and Malaria is an international financing and partnership organization that aims to "attract, leverage and invest additional resources to end the epidemics of HIV/AIDS, tuberculosis and malaria to support attainment of the Sustainable Development Goals established by the United Nations". In June 2001 the United Nations General Assembly endorsed the creation of a global fund to fight HIV/AIDS. This multistakeholder international organization maintains its secretariat in Geneva, Switzerland and began operations in January 2002. From January 2006, while being a 501 organization, it received status under International Organizations Immunities Act in the United States.
The Global Fund is the world's largest financier of AIDS, TB, and malaria prevention, treatment, and care programs. As of June 2019, the organization had disbursed more than US$41.6 billion to support these programs. According to the organization, in 2018 it helped finance the distribution of 227 million insecticide-treated nets to combat malaria, provided anti-tuberculosis treatment for 7.1 million people, supported 25 million people on antiretroviral therapy for AIDS, and since its founding saved 65 million lives worldwide.
The Global Fund is a financing mechanism rather than an implementing agency. Programs are implemented by in-country partners such as ministries of health, while the Global Fund secretariat, whose staff only have an office in Geneva, monitor the programs. Implementation is overseen by Country Coordinating Mechanisms, country-level committees consisting of in-country stakeholders that need to include, according to Global Fund requirements, a broad spectrum of representatives from government, NGOs, faith-based organizations, the private sector, and people living with the diseases. This system has kept the Global Fund secretariat smaller than other international bureaucracies. The model has also raised concerns about conflict of interest, as some of the stakeholders represented on the Country Coordinating Mechanisms may also receive money from the Global Fund, either as grant recipients, sub-recipients, private persons or contractors.
In January 2025, President Donald Trump’s administration implemented a comprehensive freeze on new funding for most foreign aid programs, including contributions to the Global Fund to Fight AIDS, Tuberculosis and Malaria. This action has raised concerns about the potential impact on global health initiatives, as the U.S. has been a significant donor to the Global Fund. In response, the Global Fund is seeking to increase private sector contributions to mitigate potential shortfalls resulting from reduced government funding.
Creation
At the end of the 20th century, international political will to improve coordinated efforts to fight the world's deadliest infectious diseases began to materialize. US Ambassador to the UN Richard Holbrooke recognized early on that diseases such as AIDS and Malaria posed as national security threat and advocated for policy that would shore up against those threats. Through various multilateral fora, consensus around creating a new international financial vehicle to combat these diseases emerged. In this context the World Health Organization called for a "Massive Attack on Diseases of Poverty" in December 1999. The original concept suggested tackling "malaria, tuberculosis, unsafe pregnancy, AIDS, diarrheal diseases, acute respiratory infections and measles". This list would steadily narrow to only include the three diseases the Global Fund fights today: HIV/AIDS, TB, and malaria.In April 2001, in Abuja, Nigeria at a summit of African leaders, United Nations Secretary General Kofi Annan made the first explicit public call by a highly visible global leader for this new funding mechanism, proposing "the creation of a Global Fund, dedicated to the battle against HIV/AIDS and other infectious diseases". Secretary General Annan made the first contribution to the Global Fund in 2001. Having just been named the recipient of the 2001 Philadelphia Liberty Medal, Annan announced he would donate his US$100,000 award to the Global Fund "war chest" he had just proposed creating. In June 2001 the United Nations General Assembly endorsed the creation of a global fund to fight HIV/AIDS.
The G8 formally endorsed the call for the creation of the Global Fund at its summit in July 2001 in Genoa, Italy, although pledges were significantly lower than the US$7 billion to US$10 billion annually Kofi Annan insisted was needed. According to the G8's final communique, "At Okinawa last year, we pledged to make a quantum leap in the fight against infectious diseases and to break the vicious cycle between disease and poverty. To meet that commitment and to respond to the appeal of the UN General Assembly, we have launched with the UN Secretary-General a new Global Fund to fight HIV/AIDS, malaria and tuberculosis. We are determined to make the Fund operational before the end of the year. We have committed $1.3 billion. The Fund will be a public-private partnership and we call on other countries, the private sector, foundations, and academic institutions to join with their own contributions – financially, in kind and through shared expertise."
The Global Fund's initial 18-member policy-setting board held its first meeting in January 2002, and issued its first call for proposals. The first secretariat was established in January 2002 with Paul Ehmer serving as team leader, soon replaced by Anders Nordstrom of Sweden who became the organization's interim executive director. By the time the Global Fund Secretariat became operational, the organization had received US$1.9 billion in pledges.
Microsoft founder Bill Gates was one of the first donors to provide seed money of US$100 million for the partnership. In March 2002, a panel of international public health experts was named to begin reviewing project proposals that same month. In April 2002, the Global Fund awarded its first batch of grants – worth US$378 million – to fight the three diseases in 31 countries.
Outcomes
The Global Fund’s investments have reduced deaths from HIV, tuberculosis, and malaria by 61% since 2002, saving 65 million lives. Recent efforts include lowering the cost of key treatments for drug-resistant TB by 55% and first-line HIV medications by 25%, while introducing a more effective insecticide-treated mosquito net. The Fund’s initiatives, including supporting 25 million people on antiretroviral medication, have saved $85 billion by reducing hospitalization and outpatient visits. Implementation evidence to support the scale-up of antiretroviral therapies in resource limited settings and has been instrumental in advocating for the protection of U.S. global health funding to combat these diseases effectively.Fundraising
Since the Global Fund was created in 2002, public sector contributions have constituted 95 percent of all financing raised; the remaining 5 percent comes from the private sector or other financing initiatives such as Product Red. The Global Fund states that from 2002 to July 2019, more than 60 donor governments pledged a total of US$51.2 billion and paid US$45.8 billion. From 2001 through 2018, the largest contributor to fund was global health funding by the United States, followed by France, the United Kingdom, Germany, and Japan. The donor nations with the largest percent of gross national income contributed to the fund from 2008 through 2010 were Sweden, Norway, France, the United Kingdom, the Netherlands, and Spain. Per law in the United States, funding for the Global Fund cannot exceed one-third of total contributions from all donors to the Global Fund.The Global Fund typically raises and spends funds during three-year "replenishment" fund-raising periods. Its first replenishment was launched in 2005, the second in 2007, the third in 2010, the fourth in 2013, and the fifth in 2016. As part of the public-private partnership, all stakeholders play an important role in resource mobilisation efforts - including communities and civil society organisations. In 2011, at the 4th Partnership Forum held in São Paulo, Brazil, the Global Fund Advocates Network was founded. Following which regional entities - GFAN Africa and GFAN Asia-Pacific were also established.
Alarms were raised prior to the third replenishment meeting in October 2010 about a looming deficit in funding, which would have led to people undergoing ARV treatment losing access, increasing the chance of them becoming resistant to treatment. UNAIDS Executive Director Michel Sidibé dubbed the scenario of a funding deficit an "HIV Nightmare". The Global Fund stated it needed at least US$20 billion for the third replenishment, and US$13 billion just to "allow for the continuation of funding of existing programs". Ultimately, US$11.8 billion was mobilized at the third replenishment meeting, with the United States being the largest contributor – followed by France, Germany, and Japan. The Global Fund stated the US$1.2 billion lack in funding would "lead to difficult decisions in the next three years that could slow down the effort to beat the three diseases".
In November 2011, the organization's board cancelled all new grants for 2012, only having enough money to support existing grants. However, following the Global Fund's May 2012 board meeting, it announced that an additional US$1.6 billion would be available in the 2012-2014 period for investment in programs.
In December 2013, the fourth replenishment meeting was held in Washington, D.C. US$12 billion was pledged in contributions from 25 countries, as well as the European Commission, private foundations, corporations, and faith-based organizations for the 2014–2016 period. It was the largest amount ever committed to fighting the three diseases.
The fifth replenishment meeting took place in September 2016 in Montreal, Canada, and was hosted by Canadian Prime Minister Justin Trudeau. Donors pledged US$12.9 billion for the 2017–2019 period.
France held the sixth replenishment meeting in 2019 in Lyon, hosted by President Emmanuel Macron raising US$14.02 billion for 2020–2022.
The seventh replenishment meeting was hosted by the United States on 19–21 September 2022 in New York City hosted by President Joe Biden, announced by Secretary of State Antony Blinken. The final total was a new record amount of funding, US$15.7 billion.
The Global Fund’s Eighth Replenishment Summit will take place on Friday, 21 November 2025, in Johannesburg, South Africa. The UK has currently committed £850m to this, representing at 15 percent cut on the UK's previous contribution.