Coprecipitation
In chemistry, coprecipitation or co-precipitation is the carrying down by a precipitate of substances normally soluble under the conditions employed. Analogously, in medicine, coprecipitation is specifically "an assay designed to purify a single antigen from a complex mixture using a specific antibody attached to a beaded support".
Coprecipitation is an important topic in chemical analysis, where it can be undesirable, but can also be usefully exploited. In gravimetric analysis, which consists on precipitating the analyte and measuring its mass to determine its concentration or purity, coprecipitation is a problem because undesired impurities often coprecipitate with the analyte, resulting in excess mass. This problem can often be mitigated by "digestion" or by redissolving the sample and precipitating it again.
On the other hand, in the analysis of trace elements, as is often the case in radiochemistry, coprecipitation is often the only way of separating an element. Since the trace element is too dilute to precipitate by conventional means, it is typically coprecipitated with a carrier, a substance that has a similar crystalline structure that can incorporate the desired element. An example is the separation of francium from other radioactive elements by coprecipitating it with caesium salts such as caesium perchlorate. Otto Hahn is credited for promoting the use of coprecipitation in radiochemistry.
There are three main mechanisms of coprecipitation: inclusion, occlusion, and adsorption. An inclusion occurs when the impurity occupies a lattice site in the crystal structure of the carrier, resulting in a crystallographic defect; this can happen when the ionic radius and charge of the impurity are similar to those of the carrier. An occlusion occurs when an adsorbed impurity gets physically trapped inside the crystal as it grows. An adsorbate is an impurity that is weakly, or strongly, bound to the surface of the precipitate.
Besides its applications in chemical analysis and in radiochemistry, coprecipitation is also important to many environmental issues related to water resources, including acid mine drainage, radionuclide migration around waste repositories, toxic heavy metal transport at industrial and defense sites, metal concentrations in aquatic systems, and wastewater treatment technology.
Coprecipitation is also used as a method of magnetic nanoparticle synthesis.
Distribution between precipitate and solution
There are two models describing of the distribution of the tracer compound between the two phases :- Doerner-Hoskins law :
- Berthelot-Nernst law:
For D and λ greater than 1, the precipitate is enriched in the tracer.
Depending on the co-precipitation system and conditions either λ or D may be constant.
The derivation of the Doerner-Hoskins law assumes that there in no mass exchange between the interior of the precipitating crystals and the solution. When this assumption is fulfilled, then the content of the tracer in the crystal is non-uniform. When the Berthelot-Nernst law applies, then the concentration of the tracer in the interior of the crystal is uniform. This is the case when diffusion in the interior is possible or when the initial small crystals are allowed to recrystallize. Kinetic effects play a role.