Gelber is known for her research on the intracellular mechanisms of learning and behavior. She demonstrated that Paramecium aurelia could form associations after training, reminiscent of associative learning in multicellular organisms. She suggested that these behavior modifications could be produced through modification of biological macromolecules such as protein or RNA-protein complexes, influencing the dynamic equilibrium of said key molecules. Her findings were contested by contemporaries such as Donald D. Jensen, who criticized the use of protozoans in comparative learning studies.