6-Hydroxytryptamine
6-Hydroxytryptamine is a serotonin receptor modulator of the tryptamine family related to serotonin. It is a positional isomer of serotonin and of 4-hydroxytryptamine.Pharmacology
6-Hydroxytryptamine shows dramatically reduced affinity for serotonin receptors, including the serotonin 5-HT1A, 5-HT1B, 5-HT2A, and 5-HT2C receptors, compared to serotonin, 4-hydroxytryptamine, 5-methoxytryptamine, and certain other tryptamines. It did not produce hyperlocomotion in rodents but did partially reverse reserpine-induced hypoactivity. 6-Hydroxytryptamine appears to be less susceptible to metabolism by monoamine oxidase than serotonin.History
6-Hydroxytryptamine was first described in the scientific literature by the 1950s.Derivatives
Certain β-carbolines and harmala alkaloids, such as harmol, harmalol, and tetrahydroharmol, as well as their O-methyl analogues including harmine, harmaline, and tetrahydroharmine, are notable in being naturally occurring cyclized tryptamine derivatives of 6-hydroxytryptamine. The same is true of certain iboga alkaloids, such as tabernanthine and ibogaline. Tabernanthalog is a synthetic simplified ibogalog analogue of tabernanthine that is under development for use as a potential pharmaceutical drug in the treatment of neuropsychiatric disorders.