4-D (psychedelic)

4-D, also known as 4-trideuteromethoxy-3,5-methoxyphenethylamine or as 4-trideuteromescaline, is a lesser-known psychedelic drug of the scaline family. It is one of the few drugs that bears deuterium. It is a deuterated analog of mescaline. It may be prepared either as a sulfate salt or a hydrochloride salt. 4-D was first synthesized by Alexander Shulgin. In his book PiHKAL, the dosage is listed as approximately 200–400 mg for the sulfate salt, and 178–356 mg for the hydrochloride salt. 4-D lasts for approximately 12 hours. It causes closed-eye visuals, mild open-eye visuals, color distortion, and mydriasis. Very little data exists about the pharmacological properties, metabolism, and toxicity of 4-D. The drug does not seem to be a controlled substance in Canada as of 2025.