2CB7
2CB7, also known as 2C-B-5-hemiFLY-β7, is a serotonin receptor modulator of the phenethylamine, 2C, and benzofuran families related to 2C-B. It is a cyclized phenethylamine or conformationally restrained derivative of 2C-B in which the 5-methoxy group has been cyclized into a dihydrofuran ring and the β position has been connected with the dihydrofuran ring via a propyl group to form a cycloheptane ring to form a tricyclic structure.
The compound has syn and anti stereoisomers, with these isomers also being racemic mixtures of - and - enantiomers. The isomers of 2CB7 show affinity for the serotonin 5-HT2A receptor, with values of 74 to 170nM for syn-2CB7 and 170 to 200nM for anti-2CB7. These affinities were dramatically lower than those of 2C-B.
2CB7 was first described in the scientific literature by Michael Robert Braden and David E. Nichols and colleagues in 2006. It was developed as part of scientific research into serotonin 5-HT2A receptor ligand interactions.