Transmembrane protein 222
Transmembrane protein 222 is a protein that in humans is encoded by the TMEM222 gene. One notable feature of the protein encoded by this gene is the presence of three predicted transmembrane domains. The TMEM222 protein is predicted to most likely localize to the secretory vesicles.
Gene Features
TMEM222 has a domain of unknown function. Aliases of this gene include DKFZP564D0478, RP11-4K3__A.4, C1orf160, and MGC111002. Accession NM_032125.2, the longest coding sequence, encodes a protein of 208 amino acid residues, which is considered the consensus coding sequence. There are two isoforms of the protein encoded by this gene. They are similar except the second is lacking the first 96 amino acid residues that are present in the first.Gene Expression
ACEVIEW has labeled TMEM222 as highly expressed with 3.8 times more expression than the average gene in the database. There is expression evidence from 166 tissues including brain, lung, colon, kidney, and placenta.Homology
Orthologs and distant homologs of the human TMEM222 have been identified throughout Eukaryota especially in plants and animals. No paralogs of this gene have been found in the human genome.| Genus/Species | Common name | Accession number | Length | Similarity | Identity |
| Rattus norvegicus | Rat | NP_001107252.1 | 208aa | 99% | 96% |
| Canis familiaris | Dog | XP_852505.1 | 208aa | 98% | 96% |
| Mus musculus | Mouse | NP_079943.2 | 208aa | 96% | 95% |
| Sus scrofa | Pig | XP_003127773.1 | 208aa | 97% | 94% |
| Equus caballus | Horse | XP_001917747.1 | 207aa | 94% | 93% |
| Gallus gallus | Chicken | XP_417729.1 | 182aa | 90% | 85% |
| Danio rerio | Zebrafish | NP_001013334.1 | 174aa | 83% | 71% |
| Anopheles gambiae | Mosquito | XP_320483.3 | 197aa | 66% | 53% |
| Drosophila melanogaster | Fruit Fly | NP_723362.1 | 196aa | 74% | 61% |
| Caenorhabditis elegans | Nematode | NP_494762.2 | 168aa | 72% | 55% |
| Phytophthora infestans | Late Blight | XP_002902629.1 | 186aa | 59% | 48% |
| Zea mays | Corn | NP_001144071.1 | 233aa | 61% | 44% |
| Oryza sativa | Rice | NP_001051577.1 | 204aa | 61% | 43% |
| Arabidopsis thaliana | Thall cress | NP_190673.1 | 231aa | 55% | 36% |
| Homo sapiens | Human | NP_115501.2 | 208 | - | - |