Small nucleolar RNA SNORA75

In molecular biology, U23 belongs to the H/ACA class of snoRNAs. snoRNAs bind a number of proteins to form snoRNP complexes. This class are thought to guide the sites of modification of uridines to pseudouridines by forming direct base pairing interactions with substrate RNAs. Targets include ribosomal and spliceosomal RNAs as well as the Trypanosoma spliced leader RNA as possibly other, still unknown cellular RNAs. U23 can direct the pseudouridylation of U97 in human 18S rRNA. U23 is encoded within intron 12 of the nucleolin gene in human, mouse, rat chicken, and Xenopus laevis.