Seltorexant

Seltorexant, also known by its developmental code names MIN-202 and JNJ-42847922, is an orexin antagonist medication which is under development for the treatment of depression, insomnia, and Alzheimer's disease. It is a selective antagonist of the orexin OX₂ receptor. The medication is taken orally.

Side effects

Seltorexant shows over 100-fold greater binding affinity for the OX₂ receptor over the OX₁ receptor. This is in contrast to other orexin receptor antagonists like suvorexant, lemborexant, and daridorexant, which are all dual [orexin receptor antagonist]s.

Seltorexant has fast absorption with a time to peak levels of 0.3 to 1.5hours and has a relatively short duration with an elimination half-life of only 2 to 3hours. No residual effects of the medication were observed 4hours after daytime administration. The pharmacokinetics of seltorexant are considered to be ideal for sleep induction. Seltorexant is metabolized by the cytochrome P450 enzyme CYP3A4.

Seltorexant is a small-molecule compound and is structurally related to other clinically used orexin receptor antagonists.

As of October 2025, seltorexant is in phase 3 clinical trials for treatment of major depressive disorder and phase 2 trials for treatment of insomnia and Alzheimer's disease. It was also under investigation for the treatment of sleep apnea, but no recent development has been reported for this indication. Seltorexant is under development by Minerva Neurosciences and Johnson & Johnson's Janssen Pharmaceuticals.
Seltorexant is being explored at doses of 5 to 80mg. In the early clinical trials conducted so far, seltorexant has been found to improve depression scores on the Hamilton Depression Rating Scale in people with MDD and to improve sleep onset, total sleep time, time awake after sleep onset, and sleep efficiency in people with MDD and/or insomnia.