Nor-LSD
Nor-LSD, or norLSD, also known as N,N''-diethyl-6-norlysergamide or as N''-desmethyllysergic acid diethylamide, is a serotonin receptor modulator and putative psychedelic of the lysergamide family related to lysergic acid diethylamide. It is the analogue of LSD in which the methyl group at the 6 position of the ergoline ring system has been removed.
Use and effects
According to Alexander Shulgin, nor-LSD showed no psychedelic effects at assessed doses of up to 500μg in humans, whereas LSD was active at doses as low as 50μg. Higher doses of nor-LSD do not appear to have been assessed.Pharmacology
Pharmacodynamics
Nor-LSD showed 5- to 29-fold lower affinity for the serotonin 5-HT2 receptor compared to LSD. It also showed affinity for the serotonin 5-HT1 receptor. In another more recent study however, nor-LSD showed similar or even higher affinities, activational potencies, and/or efficacies at the serotonin 5-HT1A, 5-HT2A, and 5-HT2B receptors as LSD, whereas it showed 36-fold lower affinity for the serotonin 5-HT2C receptor compared to LSD.Nor-LSD failed to completely substitute for LSD in rodent drug discrimination tests even at very high doses. The greatest degree of substitution with nor-LSD was 75% at a dose of 7,420nM/kg, whereas 100% substitution occurred with LSD at a dose of 186nM/kg. The was 2,594nM/kg for nor-LSD and 46nM/kg for LSD. Hence, nor-LSD was approximately 56-fold less potent than LSD in terms of producing LSD-like effects in rodents and failed to produce full LSD-like effects even at the highest assessed dose. In another study, nor-LSD failed to produce LSD-like electroencephalogram changes in rabbits.