Isaac ben Melchizedek
Isaac ben Melchizedek, was a rabbinic scholar from Siponto, Italy, and one of the first medieval scholars to have composed a commentary on the Mishnah, of which only his commentary on Seder Zera'im survives. Elements of the Mishnaic order of Taharot are also cited in his name by the Tosafists, but the complete work is no longer extant.
Background
Rabbi Isaac ben Melchizedek was the son of an astute Italian Jewish Talmudist. Rabbi Isaac eventually moved away from his home town and settled in Salerno. He is known to have fathered at least two sons: Judah and Shiloh. It was in Salerno that Isaac's son, Judah, met with the renowned Jewish traveler, Benjamin of Tudela. Benjamin of Tudelo referred to his father, Rabbi Isaac, as "the great rabbi." In Italy, Rabbi Isaac maintained a correspondence with Rabbi Yaakov ben Meir, known also as Rabbeinu Tam. Shiloh, his son, is mentioned in Sefer ha-'Iṭṭur.From Naples by sea to the city of Salerno, where the Christians have a school of medicine. About 600 Jews dwell there. Among the scholars are R. Judah, son of R. Isaac, the son of Melchizedek, the great Rabbi, who came from the city of Siponto.
Isaac's Mishnah commentary is thought to have had a wide dissemination among Jewish communities throughout the Mediterranean littoral and Egypt, as some of his words are cited and argued against by great Jewish scholars in Fostat and in Posquières. Rabbi Abraham b. David of Posquières referred to Rabbi Isaac by the epithet, Ha-Rav ha-Yevani, meaning, "the Grecian rabbi," seeing that part of southern Italy was at that time under Byzantine influence. Rabbi Isaac's work is also widely cited by Solomon Sirilio where, occasionally, he decides in favor of Isaac's interpretation of a passage in the Mishnah over that of the later scholar, Maimonides. Both, Ishtori Haparchi and Rabbi Chaim Joseph David Azulai, make mention of him in their writings. Rabbi Meir of Rothenburg mentions him with respect to teachings in Mishnah Kelim 8:6; Nega'im 11:1.
Rabbi Isaac's commentary of Seder Zera'im has been printed in the 1890 Romm Wilna edition of the Babylonian Talmud. In most editions of the Berakhot tractate, his commentary on Seder Zera'im appears in its entirety. The portion of Rabbi Isaac's Mishnah commentary of Bikkurim 2:4, unto the end of the tractate, is of special importance, as it has been printed in Shimshon of Sens's commentary of the Mishnah where he left no commentary of his own. In Rabbi Isaac ben Melchizedek's commentary, besides citing from the two Talmuds, he frequently makes use of other classical rabbinic sources, such as the Tosefta, the Sifra on Leviticus, Sifrei Zuṭa on the Book of Numbers, the Aramaic Targum, the Seder 'Olam, the Sefer Arukh of Rabbi Nathan ben Jehiel of Rome, the commentary written by Rabbi Hai Gaon on the Mishnaic orders of Zera'im and Ṭaharot, as well as cites elements taken from R. Nissim's Sefer Mafteaḥ.