Fight-or-flight response


The fight-or-flight or fight-flight-freeze-or-fawn response, also known as hyperarousal or acute stress response, is a physiological reaction that occurs in response to a perceived harmful event, attack, or threat to survival. It was first described by Walter Bradford Cannon in 1914 which he referred to as "the necessities of fighting or flight" in 1915. His theory states that animals react to threats with a general discharge of the sympathetic nervous system, preparing the animal for fighting or fleeing. More specifically, the adrenal medulla produces a hormonal cascade that results in the secretion of catecholamines, especially norepinephrine and epinephrine. The hormones estrogen, testosterone, and cortisol, as well as the neurotransmitters dopamine and serotonin, also affect how organisms react to stress. The hormone osteocalcin might also play a part.
This response is recognised as the first stage of the general adaptation syndrome that regulates stress responses among vertebrates and other organisms.

Name

Originally understood as the "fight-or-flight" response in Cannon's research, the state of hyperarousal results in several responses beyond fighting or fleeing. This has led people to calling it the "fight, flight, freeze" response, "fight-flight-freeze-fawn" or "fight-flight-faint-or-freeze", among other variants.
The wider array of responses, such as freezing, flop, faint, flee and fright, has led researchers to use more neutral or accommodating terminology such as "hyperarousal" or the "acute stress response".

Physiology

Autonomic nervous system

The autonomic nervous system is a control system that acts largely unconsciously and regulates heart rate, digestion, respiratory rate, pupillary response, urination, and sexual arousal. This system is the primary mechanism in control of the fight-or-flight response and its role is mediated by two different components: the sympathetic nervous system and the parasympathetic nervous system.The fight or flight response is your body's built‑in survival mechanism. It kicks in without conscious thought, preparing you to either confront danger or escape it. This acute stress response is controlled by a part of your body's autopilot system called the autonomic nervous system, which is composed of two branches: the sympathetic nervous system activates your fight or flight response, and the parasympathetic nervous system helps you calm down once the danger passes.

Sympathetic nervous system

The sympathetic nervous system originates in the spinal cord and its main function is to activate the arousal responses that occur during the fight-or-flight response. The sympathetic nervous system transfers signals from the dorsal hypothalamus, which activates the heart, increases vascular resistance, and increases blood flow, especially to the muscle, heart, and brain tissues. It activates the adrenal medulla, releasing catecholamines that amplify the sympathetic response. Additionally, this component of the autonomic nervous system utilizes and activates the release of norepinephrine by the adrenal glands in the reaction.

Parasympathetic nervous system

The parasympathetic nervous system originates in the sacral spinal cord and medulla, physically surrounding the sympathetic origin, and works in concert with the sympathetic nervous system. It is known as the calming portion of the autonomic nervous system. While the sympathetic nervous system is activated, the parasympathetic nervous system decreases its response. Efferent vagal fibers originating from the nucleus ambiguous fire in parallel to the respiratory system, decreasing the vagal cardiac parasympathetic tone. After the fight or flight response, the parasympathetic system's main function is to activate the "rest and digest" response and return the body to homeostasis. This system utilizes and activates the release of the neurotransmitter acetylcholine.

Reaction

The reaction begins in the amygdala, which triggers a neural response in the hypothalamus. The initial reaction is followed by activation of the pituitary gland and secretion of the hormone ACTH. The adrenal gland is activated almost simultaneously, via the sympathetic nervous system, and releases the hormone epinephrine. The release of chemical messengers results in the production of the hormone cortisol, which increases blood pressure, blood sugar, and suppresses the immune system.
The initial response and subsequent reactions are triggered in an effort to create a boost of energy. This boost of energy is activated by epinephrine binding to liver cells and the subsequent production of glucose. Additionally, the circulation of cortisol functions to turn fatty acids into available energy, which prepares muscles throughout the body for response.
Catecholamine hormones, such as adrenaline or noradrenaline, facilitate immediate physical reactions associated with a preparation for violent muscular action.

Function of physiological changes

The physiological changes that occur during the fight or flight response are activated to give the body increased strength and speed in anticipation of fighting or running. Some of the specific physiological changes and their functions include:
  • Increased blood flow to the muscles and brain activated by diverting blood flow from other parts of the body to make taking quick action easier, this decreases blood flow to the digestive system, which reduces appetite and the ability to digest food.
  • Increased blood pressure and heart rate enhance cardiac output in order to supply the body with more energy.
  • The liver secretes increased amounts of glucose and fats into the blood to provide the body with a fuel source to meet energy demands.
  • The respiratory rate increases to supply the oxygen necessary to help burn the extra glucose.
  • The blood clotting function of the body speeds up in order to reduce bleeding and prevent excessive blood loss in the event of an injury sustained during the response.
  • Increased muscle tension in order to provide the body with extra speed and strength, which can result in trembling or shaking until the tension is released.
  • The pupils dilate to let in more light, allowing for better vision of the body's surroundings.

    Emotional components

Emotion regulation

In the context of the fight or flight response, emotional regulation is used proactively to avoid threats of stress or to control the level of emotional arousal. Emotional socialization can develop someone's ability to successfully regulate their emotions. Faced with a perceived threat those raised with supportive parental behaviors are far more likely to easily self-regulate their emotions.

Emotional reactivity

During the reaction, the intensity of emotion that is brought on by the stimulus will also determine the nature and intensity of the behavioral response. In an experiment conducted by Clayton, Lang, Leshner and Quick, they viewed the responses of 49 participants to antitobacco messages. Participants reacted in two orders of fashion after seeing the message with the individual smoker and their effects on those surrounding them. The first reaction was participants who had higher defense mechanisms, who decided to ignore the messages, while the other participants who had lower defense mechanisms, ended up arguing and becoming frustrated after viewing the antitobacco messages. Individuals with higher levels of emotional reactivity may be prone to anxiety and aggression, which illustrates the implications of appropriate emotional reaction in the fight or flight response.

Cognitive components

Content specificity

The specific components of cognitions in the fight or flight response seem to be largely negative. These negative cognitions may be characterised by: attention to negative stimuli, the perception of ambiguous situations as negative, and the recurrence of recalling negative words. There also may be specific negative thoughts associated with emotions commonly seen in the reaction.

Perception of control

relates to an individual's thoughts about control over situations and events. Perceived control should be differentiated from actual control because an individual's beliefs about their abilities may not reflect their actual abilities. Therefore, overestimation or underestimation of perceived control can lead to anxiety and aggression.

Social information processing

The social information processing model proposes a variety of factors that determine behavior in the context of social situations and preexisting thoughts. The attribution of hostility, especially in ambiguous situations, seems to be one of the most important cognitive factors associated with the fight or flight response because of its implications towards aggression.

Other animals

Evolutionary perspective

An evolutionary psychology explanation is that early animals had to react to threatening stimuli quickly and did not have time to psychologically and physically prepare themselves. The fight or flight response provided them with the mechanisms to rapidly respond to threats against survival.

Examples

A typical example of the stress response is a grazing zebra. If the zebra sees a lion closing in for the kill, the stress response is activated as a means to escape its predator. The escape requires intense muscular effort, supported by all of the body's systems. The sympathetic nervous system's activation provides for these needs. A similar example involving fight is of a cat about to be attacked by a dog. The cat shows accelerated heartbeat, piloerection, and pupil dilation, all signs of sympathetic arousal. Note that the zebra and cat still maintain homeostasis in all states.
In July 1992, Behavioral Ecology published experimental research conducted by biologist Lee A. Dugatkin where guppies were sorted into "bold", "ordinary", and "timid" groups based upon their reactions when confronted by a smallmouth bass after which the guppies were left in a tank with the bass. After 60 hours, 40 percent of the timid guppies and 15 percent of the ordinary guppies survived while none of the bold guppies did.