Dysphagia

Dysphagia is difficulty in swallowing. Although classified under "symptoms and signs" in ICD-10, in some contexts it is classified as a condition in its own right.
It may be a sensation that suggests difficulty in the passage of solids or liquids from the mouth to the stomach, a lack of pharyngeal sensation or various other inadequacies of the swallowing mechanism. Dysphagia is distinguished from other symptoms including odynophagia, which is defined as painful swallowing, and globus, which is the sensation of a lump in the throat. A person can have dysphagia without odynophagia, odynophagia without dysphagia or both together. A psychogenic dysphagia is known as phagophobia.

Classification

Dysphagia is classified into the following major types:

Oropharyngeal dysphagia
Esophageal and obstructive dysphagia
Neuromuscular symptom complexes
Functional dysphagia is defined in some patients as having no organic cause for dysphagia that can be found.
Signs and symptoms

Some patients have limited awareness of their dysphagia, so the lack of the symptom does not exclude an underlying disease. When dysphagia goes undiagnosed or untreated, patients are at a high risk of pulmonary aspiration and subsequent aspiration pneumonia secondary to food or liquids going the wrong way into the lungs. Some people present with "silent aspiration" and do not cough or show outward signs of aspiration. Undiagnosed dysphagia can also result in dehydration, malnutrition, and kidney failure.
Some signs and symptoms of oropharyngeal dysphagia include difficulty controlling food in the mouth, inability to control food or saliva in the mouth, difficulty initiating a swallow, coughing, choking, frequent pneumonia, unexplained weight loss, gurgly or wet voice after swallowing, nasal regurgitation, and patient complaint of swallowing difficulty. When asked where the food is getting stuck, patients will often point to the cervical region as the site of the obstruction. The actual site of obstruction is always at or below the level at which the level of obstruction is perceived.
The most common symptom of esophageal dysphagia is the inability to swallow solid food, which the patient will describe as 'becoming stuck' or 'held up' before it either passes into the stomach or is regurgitated. Pain on swallowing or odynophagia is a distinctive symptom that can be highly indicative of carcinoma, although it also has numerous other causes that are not related to cancer. Achalasia is a major exception to the usual pattern of dysphagia in that swallowing of fluid tends to cause more difficulty than swallowing solids. In achalasia, there is idiopathic destruction of parasympathetic ganglia of the Auerbach's plexus of the entire esophagus, which results in functional narrowing of the lower esophagus, and peristaltic failure throughout its length.

Complications

Complications of dysphagia may include aspiration, pneumonia, dehydration, and weight loss.

Causes

The following table enumerates possible causes of dysphagia:

Location	Cause
Oral dysphagia	Inflammation and infection * Tonsillitis * Peritonsillar abscess * Stomatitis Tongue cancer Neurological * Paralysis of soft palate, usually due to diphtheria in children and bulbar palsy in adults * Bell's palsy Xerostomia/dry mouth – e.g., Sjogren's syndrome
Pharyngeal dysphagia	Lumen: * Impacted foreign body Wall: * Pharyngitis * Paterson-Kelly syndrome * Pharyngeal spasms * Malignant neoplasm Outside the wall: * Retropharyngeal abscess * Lymphadenopathy of cervical lymph nodes * Thyroid malignancy * Eagle syndrome * Rabies
Esophageal dysphagia	Lumen * Impacted foreign body Wall: * Esophageal atresia * Benign strictures, due to reflux esophagitis, swallowed corrosives, tuberculosis, and radiotherapy, scleroderma/systemic sclerosis * Spasms, due to achalasia, Paterson-Kelly syndrome, esophageal webs, and esophageal rings * Neoplasms, such as esophageal cancer, esophageal leiomyoma * Nervous disorders, such as bulbar palsy, pseudobulbar palsy, post-vagotomy, myasthenia gravis * Crohn's disease * Candida esophagitis * Eosinophilic esophagitis Outside the wall: * Retrosternal goitre * Malignancy * Zenker's diverticulum * Aortic aneurysm * Mediastinal growth * Dysphagia lusoria * Periesophagitis * Hiatus hernia * Tight hiatus repairs/laparoscopic fundoplication; gastric banding

Difficulty with or inability to swallow may be caused or exacerbated by the use of opioids. Other drugs such as cocaine may also induce it.

Diagnosis

Esophagoscopy and laryngoscopy can give direct view of lumens.
Esophageal motility study is useful in cases of esophageal achalasia and diffuse esophageal spasms.
Exfoliative cytology can be performed on esophageal lavage obtained by esophagoscopy. It can detect malignant cells in the early stage.
Ultrasonography and CT scan are not very useful in finding causes of dysphagia, but can detect masses in the mediastinum and aortic aneurysms.
FEES, sometimes with sensory evaluation, is usually done by a Medical Speech Pathologist or Deglutologist. This procedure involves the patient eating different consistencies as above.
Swallowing sounds and vibrations could be potentially used for dysphagia screening, but these approaches are in the early research stages.
Differential diagnosis

All causes of dysphagia are considered as differential diagnoses. Some common ones are:

Esophageal atresia
Paterson-Kelly syndrome
Zenker's diverticulum
Esophageal varices
Benign strictures
Achalasia
Esophageal diverticula
Scleroderma
Diffuse esophageal spasm
Polymyositis
Webs and rings
Esophageal cancer
Eosinophilic esophagitis
Hiatus hernia, especially paraesophageal type
Dysphagia lusoria
Stroke
Fahr's disease
Wernicke encephalopathy
Charcot–Marie–Tooth disease
Parkinson's disease
Multiple sclerosis
Amyotrophic lateral sclerosis
Rabies
Cervical Spondylosis

Esophageal dysphagia is almost always caused by disease in or adjacent to the esophagus, but occasionally the lesion is in the pharynx or stomach. In many of the pathological conditions causing dysphagia, the lumen becomes progressively narrowed and indistensible. Initially, only fibrous solids cause difficulty, but later the problem can extend to all solids and even to liquids. Patients with difficulty swallowing may benefit from thickened fluids if the person is more comfortable with those liquids, although, so far, there is no scientific study that proves that those thickened liquids are beneficial.
Dysphagia may manifest as the result of autonomic nervous system pathologies including stroke and ALS, or due to rapid iatrogenic correction of an electrolyte imbalance.
In older adults, presbyphagia - the normal healthy changes in swallowing associated with age - should be considered as an alternative explanation for symptoms.

Treatments

There are many ways to treat dysphagia, such as swallowing therapy, dietary changes, feeding tubes, certain medications, and surgery. Treatment for dysphagia is managed by a group of specialists known as a multidisciplinary team. Members of the multidisciplinary team include: a speech language pathologist specializing in swallowing disorders, primary physician, gastroenterologist, nursing staff, respiratory therapist, dietitian, occupational therapist, physical therapist, pharmacist, and radiologist. The role of the members of the multidisciplinary team will differ depending on the type of swallowing disorder present. For example, the swallowing therapist will be directly involved in the treatment of a patient with oropharyngeal dysphagia, while a gastroenterologist will be directly involved in the treatment of an esophageal disorder.

Treatment strategies

The implementation of a treatment strategy should be based on a thorough evaluation by the multidisciplinary team. Treatment strategies will differ on a patient-to-patient basis and should be structured to meet the specific needs of each individual patient. Treatment strategies are chosen based on a number of different factors, including diagnosis, prognosis, reaction to compensatory strategies, severity of dysphagia, cognitive status, respiratory function, caregiver support, and patient motivation and interest.

Oral vs. nonoral feeding

Adequate nutrition and hydration must be preserved at all times during dysphagia treatment. The overall goal of dysphagia therapy is to maintain or return the patient to oral feeding. However, this must be done while ensuring adequate nutrition and hydration and a safe swallow. If oral feeding results in increased mealtimes and increased effort during the swallow, resulting in not enough food being ingested to maintain weight, a supplementary nonoral feeding method of nutrition may be needed. In addition, if the patient aspirates food or liquid into the lungs despite the use of compensatory strategies, and is therefore unsafe for oral feeding, nonoral feeding may be needed. Nonoral feeding includes receiving nutrition through a method that bypasses the oropharyngeal swallowing mechanism, including a nasogastric tube, gastrostomy, or jejunostomy. Some people with dysphagia, especially those nearing the end of life, may choose to continue eating and drinking orally even when it has been deemed unsafe. This is known as "risk feeding".

Swallowing difficulties in dementia

A 2018 Cochrane review found no conclusive evidence about the immediate and long-term effects of modifying the thickness of fluids for swallowing difficulties in people with dementia. While thickening fluids may have an immediate positive effect on swallowing and improving oral intake, the long-term impact on the health of the person with dementia should also be considered.