DiPLA

DiPLA, also known as N,''N-diisopropyllysergamide or as lysergic acid diisopropylamide, is a putative serotonergic psychedelic of the lysergamide family related to lysergic acid diethylamide. It is the analogue of LSD in which the N'',N-diethyl groups have been replaced with N,''N''-diisopropyl groups.

Use and effects

DiPLA is not known to have been assessed in humans.

Interactions

Pharmacology

Pharmacodynamics

In an early study, DiPLA showed 23.2% of the antiserotonergic activity of LSD in the isolated rat uterus and hence was about 4-fold less potent than LSD in this assay. Subsequently, DIPLA was reported to have an affinity for the serotonin 5-HT_2A receptor of 9.0 to 20.2nM, which was about 4- to 9-fold lower than that of LSD. It is an agonist of the serotonin 5-HT_2A receptor and also interacts with other receptors such as the serotonin 5-HT_1A receptor, the serotonin 5-HT_2C receptor, and dopamine receptors. DIPLA fully substituted for LSD in rodent drug discrimination tests, suggesting that it could have psychedelic effects in humans. Unlike other assessed lysergamides however, DIPLA was much less potent than LSD, about 8-fold so in the drug discrimination test.

History

DiPLA was first described in the scientific literature by Albert Hofmann and colleagues by 1955. Subsequently, it was studied in more detail by David E. Nichols and colleagues in the 1990s and thereafter.