Dexibuprofen
Dexibuprofen is a nonsteroidal anti-inflammatory drug. It is the active dextrorotatory enantiomer of ibuprofen. Most ibuprofen formulations, as well as other drugs of the profen drug class, contain a racemic mixture of both isomers.
Dexibuprofen is a chiral switch of racemic ibuprofen. The chiral carbon in dexibuprofen is assigned an absolute configuration of per the Cahn–Ingold–Prelog rules. Dexibuprofen is also called --ibuprofen.
Ibuprofen is an α-arylpropionic acid used largely in the treatment of rheumatoid arthritis and widely used over-the counter drug for headache and minor pains. This drug has a chiral center and exists as a pair of enantiomers. -Ibuprofen, the eutomer, is responsible for the desired therapeutic effect. The inactive -enantiomer, the distomer, undergoes a unidirectional chiral inversion to give the active -enantiomer, the former acting as a prodrug for the latter. That is, when the ibuprofen is administered as a racemate the distomer is converted in vivo into the eutomer while the latter is unaffected.