Chalepensin


Chalepensin is a chemical compound of the furanocoumarin class. Originally isolated in 1967 from fringed rue, from which it derives its name, it has also been found in other plants of the genus Ruta including common rue and mountain rue.

Chemical properties

Chalepensin forms colorless crystalline needles with a melting point of 82-83 °C.

Research

Chalepensin has been shown to have antifertility effects in female rats. This may be the result of toxic effects chalepensin has on the ovaries. This antifertility effect may provide some scientific evidence in support of the traditional uses of fringed rue and modern use of rue oil in South America as an abortifacient.
Chalepensis has also been shown to have antibacterial activity against Streptococcus mutans and Methicillin-resistant [Staphylococcus aureus|methicillin-resistant Staphylococcus aureus].

Related compounds

Several chemical compounds that have the same core chemical structure as chalepensin are known, including chalepin, rutamarin, 5-methoxychalepensin, and 5,8-dimethoxychalepensin.