ALA-10

ALA-10, also known as 1-acetyl-LAE, is a psychedelic drug of the lysergamide family related to lysergic acid diethylamide. It is the 1-acetyl derivative of LAE-32. 1-Acetylated lysergamides like ALD-52 are thought to function as prodrugs via deacetylation to the 1-unsubstituted analogues, which in the case of ALD-52 is LSD.

Use and effects

ALA-10 is active at a dose of approximately 1.2mg orally in humans and has around 7 to 10% of the potency of LSD. It produces LSD-like psychic effects. It is said to have a quicker onset and shorter duration than LSD. For comparison, LAE-32, has a dose range of 0.5 to 1.6mg, about 5 to 10% of the activity of LSD, and a likewise faster onset and shorter duration than LSD. Both ALA-10 and LAE-32 are said to produce only slight or weak hallucinogenic effects. ALA-10 is around 15-fold less potent than ALD-52, which is roughly equipotent with LSD.

Interactions

Pharmacology

Pharmacodynamics

ALA-10 shows antiserotonergic activity in the isolated rat uterus of about 39% of that of LSD but about 3times stronger than that of LAE-32. Its pyretogenic potency in rabbits is only about 1% of that of LSD.

History

ALA-10 was first described in the scientific literature by the late 1950s.