3C (psychedelics)


3C, also known as 4-substituted 3,5-dimethoxyamphetamines, substituted 3,4,5-trimethoxyamphetamine analogues, or 3C-scalines, is a general name for the family of psychedelic amphetamines containing methoxy groups at the 3 and 5 positions of the benzene ring. These compounds are analogues of 3,4,5-trimethoxyamphetamine.
The 3C drugs are not the amphetamine counterparts of the 2C drugs, which are 4-substituted 2,5-dimethoxyphenethylamines. Instead, the DOx drugs, which are 4-substituted 2,5-dimethoxyamphetamines, are the amphetamine counterparts of the 2C drugs. The 3C drugs are the amphetamine counterparts of scalines. Moreover, in terms of naming with the "3C" prefix, the 3C drugs are generally actually derivatives of TMA-1 with the 4-position methoxy group extended rather than having any 4-position substituent. In this regard, they would be the 3,5-dimethoxyamphetamine counterparts of the 2C-O drugs and the 2,4,5-trimethoxyamphetamine derivatives.
3C drugs have been developed and/or studied by Alexander Shulgin and Daniel Trachsel, among others. The pharmacology of 3C drugs has been studied and described.

Use and effects

Interactions

List of 3C drugs

4-Alkoxylated