3-APBT
3-APBT, also known by its former developmental code name SKF-6678 and as 3-benzothiophene, as well as 1-thia-α-methyltryptamine, is a monoamine releasing agent and serotonin receptor agonist of the benzothiophene group. It is an analogue of α-methyltryptamine in which the indole ring has been replaced with a benzothiophene ring.
The drug acts as a potent and well-balanced serotonin–norepinephrine–dopamine releasing agent. It is also a full agonist of the serotonin 5-HT2 receptors, including of the serotonin 5-HT2A, 5-HT2B, and 5-HT2C receptors. 3-APBT produces the head-twitch response, a behavioral proxy of psychedelic effects, in rodents. It does not stimulate locomotor activity in rodents, suggesting that it does not possess stimulant-type effects. The drug has been reported be a weak monoamine oxidase inhibitor, specifically of monoamine oxidase A .
3-APBT was developed by Smith, Kline & French as a potential pharmaceutical drug in the late 1950s. The drug and its positional isomer 2-APBT were reported to produce various central nervous system effects and to be useful as a "ataractics, psychic energizers, and analgetics". 3-APBT has also been reported to have appetite suppressant effects in rodents, but to have considerably lower potency than AMT as an "analeptic" in rodents.