2021–22 Gozo First Division
The 2021–22 Gozo First Division was the 75th season of the Gozo Football League First Division, the highest division in Gozitan football. The season began on 3 September 2021 and ended on 10 April 2022.
Nadur Youngsters won the league title. The bottom-placed team were relegated to the 2022–23 Gozo Second Division.
Teams
The league consisted of eight teams. Nadur Youngsters entered the season as defending champions.| Team | Home city |
| Għajnsielem | Għajnsielem |
| Kerċem Ajax | Kerċem |
| Nadur Youngsters | Nadur |
| Oratory Youths | Victoria |
| Sannat Lions | Sannat |
| Victoria Hotspurs | Victoria |
| SK Victoria Wanderers | Victoria |
| Xewkija Tigers | Xewkija |