Small nucleolar RNA SNORD93

In molecular biology, Small Nucleolar RNA SNORD93 is a non-coding RNA molecule that functions in the biogenesis of other small nuclear RNAs. This type of modifying RNA is located in the nucleolus of the Eukaryotic cell, which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA and is also often referred to as a guide RNA.
SNORD93 belongs to the C/D box class of snoRNAs, which contain the C and D box motifs. Most members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. This snoRNA is the human orthologue of mouse snoRNA MBII-336.
SNORD93 is predicted to guide the 2'O-ribose methylation of 18S ribosomal RNA residue A576.
Additionally, SNORD93 can be processed into a smaller, microRNA-like fragment that contributes to the malignant phenotype of breast cancer.
The processed piece has been shown to target Pipox, a sarcosine metabolism-related protein whose expression significantly correlates with distinct molecular subtypes of breast cancer.