Sean O'Brien
Sean O'Brien may refer to:
Sportspeople
- Seán O'Brien (Gaelic footballer), Gaelic footballer for Nemo Rangers
- Seán O'Brien (Cork hurler), Irish hurler
- Seán O'Brien (Tipperary hurler), Irish hurler
- Sean O'Brien (ice hockey), American former ice hockey left winger
- Seán O'Brien (rugby union, born 1987), former Irish rugby union international flanker for Leinster and London Irish
- Seán O'Brien (rugby union, born 1994), former Irish rugby union flanker for Connacht
- Seán O'Brien (rugby union, born 1998), Irish rugby union centre / winger for Munster
- Seán O'Brien (rugby union, born 2000), American-born Irish rugby union flanker for Connacht
- Sean O'Brien (windsurfer), Australian windsurfer
- Sean O'Brien (footballer), English footballer
Other people
- Sean O'Brien (writer), British writer
- Sean C. O'Brien, co-discoverer of buckminsterfullerene
- Sean O'Brien (labor leader), American trade unionist
- Sean O'Brien, bassist and original member of Boston rock band Come
- Sean O'Brien (Ohio politician), Democratic member of the Ohio Senate