SC 414 begins at an intersection with U.S. Route 276 south of Marietta, within GreenvilleCounty. It travels to the north-northeast and curves to the northeast and crosses Bull Creek. The highway curves to the east-southeast and has a very brief concurrency with US 25. SC 414 travels to the northeast and crosses over Mush and Johnson creeks. It travels through North Greenville University in Tigerville. On the southeastern edge of the university is an intersection with the northern terminus of SC 253. SC 414 crosses over the SouthTyger River. Then, it heads in a more easterly direction and crosses Tyger Cemetery. The highway enters Highland, where it has a very brief concurrency with SC 101. It curves to the east and passes Ebenezer Cemetery just before heading to the southeast. It curves back to the east just before meeting its eastern terminus, an intersection with SC 14.