SC 412 begins at an intersection with U.S. Route 29 west-northwest of Starr, within unincorporated Anderson County community of Holland Store. It travels in a fairly east-southeasterly direction. It crosses over Lucas Creek before it intersects SC 187. The highway crosses over Big Generostee and Generostee creeks. A short distance after crossing Weems Creek, it passes Starr–Iva Middle School. In Starr, it intersects the northern terminus of SC 181 just before it meets its eastern terminus, an intersection with SC 81. Here, the roadway continues as First Avenue.