Henry Osborne

• Henry Osborne (American politician), public official from Pennsylvania and Georgia
• Henry Osborne (admiral), British naval officer who served as Commodore Governor of Newfoundland
• Sir Henry Osborne, 11th Baronet, Irish baronet and politician
• Henry Osborne (Australian politician), Australian pastoralist, collier and politician
• Henry Osborne Havemeyer, American entrepreneur
• Henry Z. Osborne, American Republican politician