Kenazepine

Kenazepine is a benzodiazepine containing a functional alkylating moiety. The chemical formula is.

Uses

The compound functions as a research tool in pharmacology. It binds irreversibly and non-competitively to some brain benzodiazepine receptors and competitively to others, providing evidence for the existence of different receptor populations within the central nervous system. Kenazepine exhibits long-lasting anticonvulsant effects, likely due to its irreversible binding mechanism, and is used to study the heterogeneity and function of benzodiazepine receptors.
Studies show that kenazepine provides a long-lasting protection against convulsions caused by pentylenetetrazole in vivo, suggesting a similar irreversible binding mechanism in the body.